4,5-二氨基-6-羟基嘧啶合成路线 (共 13 条)
参考文献
Journal of the American Chemical Society, , vol. 67, p. 290,292
Journal of the American Chemical Society, , vol. 74, p. 411,413
Journal of the Chemical Society, , p. 474,478
Journal of the Chemical Society, , p. 4219,4224
参考文献
Yakugaku Zasshi, , vol. 77, p. 686
Chem.Abstr., , p. 16494
反应条件
N,N-dimethyl-aniline; trichlorophosphate 4 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/13141 A1, 2004 ;
Location in patent: Page 134 ;
WO 2004/013141 A1
反应条件
pyridine; tetraphosphorus decasulfide 15 h; Heating;
参考文献
Okafor; Uche; Akpanisi
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 8 p. 1589 - 1593
反应条件
1: With sodium hydroxide T=0 - 20°C; 2: With sulfuric acid T=135°C; 8 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.
Patent: WO2011/53292 A1, 2011 ;
Location in patent: Page/Page column 132 ;
WO 2011/053292 A1
参考文献
Cavalieri; Bendich
Journal of the American Chemical Society, 1950 , vol. 72, p. 2587,2593
参考文献
Cavalieri; Bendich
Journal of the American Chemical Society, 1950 , vol. 72, p. 2587,2593
参考文献
Albert; Brown
Journal of the Chemical Society, 1954 , p. 2060,2062
参考文献
Albert et al.
Journal of the Chemical Society, 1952 , p. 4219,4220
反应条件
(i) (Me3Si)2NH, (reflux), (ii) SOCl2, toluene; Multistep reaction;
参考文献
Shealy,Y.F. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 2154 - 2160