保护的4-苯基哌啶-4-羧酸合成路线 （共 15 条）
反应条件
1: With triethylamine in tetrahydrofuran 1 h; Heating / reflux; 2: With acetic acid in water pH=5;
参考文献
SOLVAY PHARMACEUTICALS GMBH
Patent: WO2007/88181 A1, 2007 ;
Location in patent: Page/Page column 59 ;
WO 2007/088181 A1
反应条件
potassium carbonate in tetrahydrofuran; water
参考文献
Hoemann, Michael Z.
Patent: US2002/177607 A1, 2002 ;
US 20020177607 A1
反应条件
N-ethyl-N,N-diisopropylamine in hydrogenchloride; N,N-dimethyl-formamide
参考文献
US5635510 A1, ;
US 5635510 A
反应条件
1: With triethylamine in tetrahydrofuran 1 h; Heating / reflux; 2: With sodium hydroxide in tetrahydrofuran; diethyl ether; water 3: With acetic acid in water pH=~ 5;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/249607 A1, 2007 ;
Location in patent: Page/Page column 56 ;
US 20070249607 A1
反应条件
hydrogenchloride in 1,4-dioxane; water
参考文献
US5780466 A1, ;
US 5780466 A
反应条件
hydrogenchloride; potassium carbonate; toluene-4-sulfonic acid in 1,4-dioxane; water
参考文献
US6465489 B1, ;
US 6465489 B1
反应条件
sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide in acetonitrile
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682
反应条件
1: 94 percent / Et3N / CH2Cl2 / 20 °C 2: 53 percent / diisobutylaluminum hydrire (DIBAL-H) / toluene / 4 h / -78 °C 3: 95 percent / aq. NaH2PO4; H2O2; aq. NaClO2 / acetonitrile View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
反应条件
1: 53 percent / diisobutylaluminum hydrire (DIBAL-H) / toluene / 4 h / -78 °C 2: 95 percent / aq. NaH2PO4; H2O2; aq. NaClO2 / acetonitrile View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 2 h;
参考文献
Burgoon, Hugh Alfred; Goodwin, Nicole Cathleen; Harrison, Bryce Alden; Healy, Jason Patrick; Liu, Ying; Mabon, Ross; Marinelli, Brett; Rawlins, David Brent; Rice, Dennis Stewart; Whitlock, Norris Andrew
Patent: US2009/264450 A1, 2009 ;
Location in patent: Page/Page column 8 ;
US 20090264450 A1
