N-boc-4-苄基-4-哌啶羧酸合成路线 （共 7 条）
反应条件
1: With methanol; lithium hydroxide; water in 1,4-dioxane T=20 - 50°C; 48 h; 2: With hydrogenchloride in 1,4-dioxane; water pH=6;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2007/125321 A2, 2007 ;
Location in patent: Page/Page column 123 ;
WO 2007/125321 A2
反应条件
1: 4-(ethoxycarbonyl)piperidine; di-tert-butyl dicarbonate With triethylamine in methanol T=0°C; 16 h; 2: With lithium hexamethyldisilazane in tetrahydrofuran T=-78 - 20°C; 1 h; 3: benzyl bromide With hydrogenchloride; methanol; sodium hydroxide; water more than 3 stages;
参考文献
D'Sidocky, Neil R.; Harris, Roy L.; Hegde, Sayee G.; Hilgraf, Robert; McCarrick, Margaret A.; McKie, Jeffrey A.; Mortensen, Deborah S.; Nadolny, Lisa; Perin-Ninkovic, Sophie M.; Sapienza, John J.; Wright, Jonathan L.
Patent: US2008/242694 A1, 2008 ;
Location in patent: Page/Page column 59 ;
US 20080242694 A1
反应条件
1: With sodium hydroxide in methanol; water T=130°C; 0.166667 h; Microwaves; 2: With hydrogenchloride in methanol; water; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: EP854870 B1, 2009 ;
Location in patent: Page/Page column 27 ;
反应条件
1: LDA / tetrahydrofuran / -78 °C 2: KOH / methanol / Heating View Scheme
参考文献
Jiang, Xiao-Hua; Song, Yan-Li; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3675 - 3678
反应条件
1: LDA / tetrahydrofuran / -78 °C 2: KOH / methanol / Heating View Scheme
参考文献
Jiang, Xiao-Hua; Song, Yan-Li; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3675 - 3678
反应条件
diazomethyl-trimethyl-silane in hexanes; benzene
T=20°C; 4 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2006/86609 A2, 2006 ;
Location in patent: Page/Page column 156 ;
WO 2006/086609 A2
反应条件
1: With triethylamine; isobutyl chloroformate in tetrahydrofuran
T=-15°C; 1 h;
2: With sodium azide in tetrahydrofuran; water
T=20°C; Curtius Rearrangement;
3: With hydrogenchloride; water
more than 3 stages;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2007/125321 A2, 2007 ;
Location in patent: Page/Page column 123-124 ;
WO 2007/125321 A2
