1-(4-甲氧基苯)-1-环丙羧酸合成路线 （共 12 条）
反应条件
potassium hydroxide in diethylene glycol 8 h; Heating;
参考文献
Mndzhoyan, Sh. L.; Tsinker, M. G.; Ovakimyan, A. R.; Ter-Zakharyan, Yu. Z.; Kazaryan, E. V.; Paronikyan, R. V.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 2 p. 114 - 118
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 2 p. 40 - 45
反应条件
potassium hydroxide in methanol 3 h; Heating;
参考文献
Kirmse, Wolfgang; Rode, Jutta
Chemische Berichte, 1986 , vol. 119, # 12 p. 3694 - 3703
反应条件
1: 85 percent / benzyltriethylammonium chloride, 50percent NaOH / CH2Cl2 / 18 h / Ambient temperature 2: (n-Bu)3SnH / diethyl ether / Ambient temperature 3: 64 percent / aq. KOH / methanol / 3 h / Heating View Scheme
参考文献
Chemische Berichte, , vol. 119, # 12 p. 3694 - 3703
反应条件
1: (n-Bu)3SnH / diethyl ether / Ambient temperature 2: 64 percent / aq. KOH / methanol / 3 h / Heating View Scheme
参考文献
Chemische Berichte, , vol. 119, # 12 p. 3694 - 3703
反应条件
1: 1.) sodium amide / 1.) toluene, heating, 1 h, 2.) overnight; heating, 6 h 2: 76.7 percent / KOH / bis-(2-hydroxy-ethyl) ether / 8 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 14, # 2 p. 114 - 118
Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 2 p. 40 - 45
反应条件
1: Et3N / acetone / 2 h / 20 °C 2: 75 percent / 3percent NaHCO3 / acetone / 4 h View Scheme
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Aleksanyan, M. V.; Ter-Zakharyan, Yu. Z.; Oganyan, Sh. G.; Engoyan, A. P.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 2 p. 115 - 119
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 2 p. 186 - 191
反应条件
sodium hydroxide; sodium dihydrogenphosphate; dipotassium peroxodisulfate in water T=25°C; pH=6.7; 0.1 h; Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 73, # 2 p. 618 - 629
反应条件
oxalyl dichloride in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
ACADIA PHARMACEUTICALS, INC.
Patent: WO2007/124136 A1, 2007 ;
Location in patent: Page/Page column 144-145 ;
WO 2007/124136 A1
反应条件
LiAlH4 in tetrahydrofuran; ethanol
反应条件
pyridine hydrochloride
T=150°C; 28 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2006/44133 A1, 2006 ;
Location in patent: Page/Page column 121 ;
WO 2006/044133 A1
