1-(4-甲氧基苯)-1-环丙羧酸合成路线 （共 12 条）
反应条件
1: methanol; ethyl acetate
2: EtSH / AlCl3 / dichloromethane
3: sodium hydride / N,N-dimethyl-formamide; mineral oil
4: (+)-Norephedrine / anhydrous xylene
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
sodium hydroxide; sodium dihydrogenphosphate; dipotassium peroxodisulfate in water
T=25°C; pH=6.7; 0.1 h; Irradiation;
参考文献
Bietti, Massimo; Capone, Alberto
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 618 - 629
