N-甲氧基-N-甲基环戊烷甲酰胺合成路线 （共 5 条）
反应条件
1: 2-methoxybromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.166667 h; 2: N-Cyclopentanecarbonyl-N,O-dimethylhydroxylamine in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Coe, Jotham W.; Bianco, Krista E.; Boscoe, Brian P.; Brooks, Paige R.; Cox, Eric D.; Vetelino, Michael G.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9964 - 9970
反应条件
1: in tetrahydrofuran T=-78 - 0°C; 1 h; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Chapal, Nicolas; McNicol, Patricia; Jette, Lucie
Patent: US2006/223884 A1, 2006 ;
Location in patent: Page/Page column 56 ;
反应条件
n-butyllithium in tetrahydrofuran
参考文献
Eli Lilly and Company
Patent: US6353008 B1, 2002 ;
Location in patent: Page column 33-34 ;
US 6353008 B1
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
1.2: tetrahydrofuran; hexane / -78 - 20 °C
2.1: BCl3 / CH2Cl2 / -78 - 20 °C
3.1: pyridine / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Coe, Jotham W.; Bianco, Krista E.; Boscoe, Brian P.; Brooks, Paige R.; Cox, Eric D.; Vetelino, Michael G.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9964 - 9970
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
1.2: tetrahydrofuran; hexane / -78 - 20 °C
2.1: BCl3 / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Coe, Jotham W.; Bianco, Krista E.; Boscoe, Brian P.; Brooks, Paige R.; Cox, Eric D.; Vetelino, Michael G.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9964 - 9970
