5-溴吲哚-2-羧酸乙酯合成路线 （共 29 条）
反应条件
polyphosphoric acid T=85°C; 3 h;
参考文献
Yang, Yan-Fang; Li, Lian-Hua; He, Yu-Tao; Luo, Jian-Yi; Liang, Yong-Min
Tetrahedron, 2014 , vol. 70, # 3 p. 702 - 707
反应条件
sulfuric acid T=80°C; 12 h;
参考文献
F. Hoffmann-La Roche AG; The designation of the inventor has not yet been filed
Patent: EP2722329 A1, 2014 ;
Location in patent: Paragraph 0169 ;
反应条件
acetic acid in ethanol
参考文献
Zeneca Limited
Patent: US6441004 B1, 2002 ;
反应条件
in ethanol; ethyl acetate
参考文献
EP2722329 A1, ;
Page/Page column ;
反应条件
Bi(NO3)3; PPA in methanol 2.5 h; Reflux;
参考文献
Sudhakara; Jayadevappa; Mahadevan; Hulikal, Vijaykumar
Synthetic Communications, 2009 , vol. 39, # 14 p. 2506 - 2515
反应条件
1: (Ethoxycarbonylmethyl)dimethyl-sulfonium bromide With caesium carbonate in anhydrous xylene T=20°C; 2: C14H13BrClNO2S in anhydrous xylene T=20°C; 3: With potassium tert-butylate in anhydrous xylene T=20°C; 72 h;
参考文献
Yang, Qing-Qing; Xiao, Cong; Lu, Liang-Qiu; An, Jing; Tan, Fen; Li, Bin-Jie; Xiao, Wen-Jing
Angewandte Chemie - International Edition, 2012 , vol. 51, # 36 p. 9137 - 9140
反应条件
1: ethyl (dimethyl-λ4-sulfanylidene)acetate With caesium carbonate in anhydrous xylene T=20°C; 0.5 h; 2: C14H14BrNO3S in anhydrous xylene T=20°C;
参考文献
Yang, Qing-Qing; Xiao, Cong; Lu, Liang-Qiu; An, Jing; Tan, Fen; Li, Bin-Jie; Xiao, Wen-Jing
Angewandte Chemie - International Edition, 2012 , vol. 51, # 36 p. 9137 - 9140
反应条件
2: polyphosphoric acid View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 13, p. 113,114
反应条件
1.1: sodium nitrite; hydrogenchloride / water / 0 °C 1.2: 0 °C 2.1: ethanol / |Inert atmosphere; |Reflux 3.1: polyphosphoric acid / 3 h / 85 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 57, p. 225 - 233
反应条件
1: hydrogenchloride; tin(ll) chloride / water / 4 h / |Cooling with ice 2: ethanol / 5 h / |Inert atmosphere; |Reflux 3: polyphosphoric acid / 3 h / 85 °C View Scheme
参考文献
Tetrahedron, , vol. 70, # 3 p. 702 - 707
