5-溴吲哚-2-羧酸乙酯合成路线 （共 29 条）
反应条件
2: polyphosphoric acid View Scheme
参考文献
Journal of the Chemical Society, , p. 473
Gazzetta Chimica Italiana, , vol. 88, p. 1147,1153, 1159
反应条件
2: polyphosphoric acid View Scheme
参考文献
Journal of the Chemical Society, , p. 473
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C; 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/12125 A1, 2009 ;
Location in patent: Page/Page column 37-38 ;
反应条件
1: 5-bromo-1H-indole-2-carboxylic acid ethyl ester With sodium hydride in N,N-dimethyl-formamide T=1 - 20°C; 2: benzyl bromide in N,N-dimethyl-formamide 12 h;
参考文献
Mutule, Ilga; Suna, Edgars; Olofsson, Kristofer; Pelcman, Benjamin
Journal of Organic Chemistry, 2009 , vol. 74, # 18 p. 7195 - 7198
反应条件
hydrogenchloride in hexane; water; dimethyl sulfoxide; mineral oil
参考文献
Pfizer Inc.
Patent: US5843972 A1, 1998 ;
US 5843972 A
反应条件
1: POCl3; 1,2-dichloro-ethane / Behandeln des Reaktionsgemisches mit wss. Natriumacetat 2: aq.-ethanolic KOH 3: N,N-dimethylaniline / Erhitzen des erhaltenen Reaktionsgemisches mit Wasser. View Scheme
参考文献
Cavallini et al.
Farmaco, Edizione Scientifica, 1958 , vol. 13, p. 113,114
反应条件
1: acetic acid; bromine 2: aq.-ethanolic NaOH View Scheme
参考文献
Kunori
Nippon Kagaku Zasshi, 1957 , vol. 78, p. 1798
Chem.Abstr., 1960 , p. 1487
反应条件
bromine in acetic acid 0.5 h;
参考文献
Hiremath, Shivayogi P.; Hiremath, Dakshayani M.; Purohit, Muralidhar G.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 10 p. 930 - 933
反应条件
lithium aluminium tetrahydride in diethyl ether 1 h; Ambient temperature;
参考文献
Dann, Otto; Char, Helmut; Fleischmann, Paul; Fricke, Helmut
Liebigs Annalen der Chemie, 1986 , # 3 p. 438 - 455
反应条件
1: 88 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature 2: 73 percent / Mangandioxid,NaCl / diethyl ether / Ambient temperature; 1.) 3-5 days, 2.) 2 h View Scheme
参考文献
Dann, Otto; Char, Helmut; Fleischmann, Paul; Fricke, Helmut
Liebigs Annalen der Chemie, 1986 , # 3 p. 438 - 455
