3-羟基-2-甲基-1-苯基丙烷-1-酮合成路线 （共 19 条）
参考文献
Plattner; Wyss
Helvetica Chimica Acta, 1941 , vol. 24, p. 483,491
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Fuson; Ross; McKeever
Journal of the American Chemical Society, 1938 , vol. 60, p. 2935
反应条件
calcium chloride in N,N-dimethyl-formamide
T=30°C; 24 h;
参考文献
Miura, Katsukiyo; Nakagawa, Takahiro; Hosomi, Akira
Journal of the American Chemical Society, 2002 , vol. 124, # 4 p. 536 - 537
反应条件
anhydrous sodium hydrogen carbonate; sodium chloride; bromine; sodium sulfite in dichloromethane; water
参考文献
Kira, Ikuo; Onishi, Norimasa
Bioscience, Biotechnology and Biochemistry, 2009 , vol. 73, # 7 p. 1640 - 1646
反应条件
ytterbium(III) triflate in tetrahydrofuran; methanol; water
24 h; Ambient temperature;
参考文献
Kobayashi; Hashiya; Ishitani; Moriwaki; Nagayama
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 2 p. 193 - 202
反应条件
sodium hydrogencarbonate in methanol; water
T=50°C; 24 h;
参考文献
Curzu, Maria Michela; Pinna, Gerard Aime; Barlocco, Daniela; Bugatti, Carlo; Cignarella, Giorgio
Synthesis, 1984 , # 4 p. 339 - 342
反应条件
ytterbium(III) triflate in tetrahydrofuran; water
24 h; Ambient temperatureother lanthanide triflates, other reaction times; Product distribution;
参考文献
Kobayashi, Shu
Chemistry Letters, 1991 , # 12 p. 2187 - 2190
反应条件
bis(η5-cyclopentadienyl)titanium dichloride in tetrahydrofuran; methanol
T=-78°C; 0.25 h;
参考文献
Hardouin; Chevallier; Rousseau; Doris
Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 1046 - 1048
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; 1,1,1,2,2,2-hexabutyl-distannane; dibutyltin difluoride in tetrahydrofuran; water
T=60°C; Reformatsky reaction; 3 h;
参考文献
Shibata, Ikuya; Kawasaki, Masatsugu; Yasuda, Makoto; Baba, Akio
Chemistry Letters, 1999 , # 7 p. 689 - 690
反应条件
1.1: BuLi / hexane; tetrahydrofuran / -78 - 0 °C
1.2: hexane; tetrahydrofuran / -78 °C
1.3: hexane; tetrahydrofuran / -78 - 20 °C
2.1: 99 percent / CaCl2 / dimethylformamide / 24 h / 30 °C
View Scheme
参考文献
Miura, Katsukiyo; Nakagawa, Takahiro; Hosomi, Akira
Journal of the American Chemical Society, 2002 , vol. 124, # 4 p. 536 - 537
反应条件
bromine; bis(tri-n-butyltin)oxide in dichloromethane
3.5 h; Ambient temperature;
参考文献
Nakata, Tadashi; Tani, Yoichiro; Hatozaki, Masayoshi; Oishi, Takeshi
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 4 p. 1411 - 1415
