1-氧杂-8-氮杂螺[4.5]癸烷-2-酮合成路线 （共 5 条）
反应条件
methanol; acetyl chloride T=0 - 20°C; 16 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/58763 A1, 2004 ;
Location in patent: Page 34 ;
WO 2004/058763 A1
反应条件
1.1: n-BuLi / tetrahydrofuran / -78 °C 1.2: tetrahydrofuran / 1 h / -78 °C 2.1: H2 / Pd/C / ethanol 3.1: p-TsOH / toluene / 3 h / Heating 4.1: AcCl; MeOH / 16 h / 0 - 20 °C View Scheme
参考文献
Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762
反应条件
1: H2 / Pd/C / ethanol 2: p-TsOH / toluene / 3 h / Heating 3: AcCl; MeOH / 16 h / 0 - 20 °C View Scheme
参考文献
Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762
反应条件
1: p-TsOH / toluene / 3 h / Heating 2: AcCl; MeOH / 16 h / 0 - 20 °C View Scheme
参考文献
Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762
反应条件
sodium tris(acetoxy)borohydride; triethylamine in dichloromethane 14 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/58763 A1, 2004 ;
Location in patent: Page 34 ;
WO 2004/058763 A1
