N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium T=-78 - 25°C; 2 h;

1: 2,4-dibromo-1,3-thiazole With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=-78°C; 0.25 h; Inert atmosphere; 2: (4-morpholinyl)methanone in tetrahydrofuran T=-78 - 0°C; 1.66667 h; Inert atmosphere;

1: 2,4-dibromo-1,3-thiazole With n-butyllithium in hexanes; diethyl ether T=-78°C; 0.5 h; Cooling with acetone-dry ice; 2: N,N-dimethyl-formamide in hexanes; diethyl ether T=-78 - 20°C; 2.5 h;