3-(N-Cbz-4-哌啶基)-3-氧代丙酸乙酯合成路线 （共 4 条）
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78 - 0°C; 2: With hydrogenchloride in tetrahydrofuran; hexane
参考文献
WO2012/158810 A1, ;
Page/Page column 113 ;
WO 2012/158810 A1
反应条件
bis(imidazol-1-yl) sulphoxide 1.) THF, RT, 20 min, 2.) THF, 2 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 17 p. 3287 - 3296
反应条件
1: sodium hydroxide / toluene; water / 4 h / 20 °C 2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C 3: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 - 0 °C View Scheme
参考文献
WO2012/158810 A1, ;
WO 2012/158810 A1
反应条件
1: sodium hydroxide / toluene; water / 4 h / 20 °C 2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C 3: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 - 0 °C View Scheme
参考文献
WO2012/158810 A1, ;
WO 2012/158810 A1
