螺[吲哚啉-3,4’-哌啶]-1’-羧酸苄酯合成路线 （共 20 条）
反应条件
1: With trifluoroacetic acid in toluene; acetonitrile T=35°C; 2: With methanol; sodium tetrahydroborate in toluene; acetonitrile T=0°C; 0.75 h; 3: With ammonium hydroxide in water; toluene; acetonitrile
参考文献
ELI LILLY AND COMPANY; HAMDOUCHI, Chafiq; LINESWALA, Jayana, Pankaj; MAITI, Pranab
Patent: WO2011/66183 A1, 2011 ;
Location in patent: Page/Page column 11 ;
WO 2011/066183 A1
反应条件
in tetrahydrofuran T=20°C; 2 h;
参考文献
Xie, Jian-Shu; Huang, Charles Q.; Fang, Yan-Yan; Zhu, Yun-Fei
Tetrahedron, 2004 , vol. 60, # 22 p. 4875 - 4878
反应条件
1: With trifluoroacetic acid in toluene; acetonitrile T=20 - 50°C; 2: With methanol; sodium tetrahydroborate in toluene; acetonitrile T=0 - 20°C; 3: With sodium hydrogencarbonate in water; toluene; acetonitrile
参考文献
WO2012/177782 A1, ;
Page/Page column 106-107 ;
WO 2012/177782 A1
反应条件
sodium tetrahydroborate in toluene T=-2°C; 0.5 h; Yield given;
参考文献
Tetrahedron, , vol. 53, # 32 p. 10983 - 10992
反应条件
1: 97 percent / K2CO3 / H2O / 58 h / 22 °C 2: (COCl)2 / toluene; dimethylformamide / 16 h / 18 °C 3: 94 percent / H2, DIEA, thioanisole / Pd/C / toluene / 22 h / 20 °C / 2068.6 Torr 4: 99 percent / TFA / CH2Cl2 / 17 h / 35 °C 5: NaBH4 / toluene / 0.5 h / -2 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 32 p. 10983 - 10992
反应条件
1: (COCl)2 / toluene; dimethylformamide / 16 h / 18 °C 2: 94 percent / H2, DIEA, thioanisole / Pd/C / toluene / 22 h / 20 °C / 2068.6 Torr 3: 99 percent / TFA / CH2Cl2 / 17 h / 35 °C 4: NaBH4 / toluene / 0.5 h / -2 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 32 p. 10983 - 10992
反应条件
1: 97 percent / K2CO3 / H2O / 58 h / 22 °C 2: (COCl)2 / toluene; dimethylformamide / 16 h / 18 °C 3: 94 percent / H2, DIEA, thioanisole / Pd/C / toluene / 22 h / 20 °C / 2068.6 Torr 4: 99 percent / TFA / CH2Cl2 / 17 h / 35 °C 5: NaBH4 / toluene / 0.5 h / -2 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 32 p. 10983 - 10992
反应条件
1: 94 percent / H2, DIEA, thioanisole / Pd/C / toluene / 22 h / 20 °C / 2068.6 Torr 2: 99 percent / TFA / CH2Cl2 / 17 h / 35 °C 3: NaBH4 / toluene / 0.5 h / -2 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 32 p. 10983 - 10992
反应条件
1: 99 percent / TFA / CH2Cl2 / 17 h / 35 °C 2: NaBH4 / toluene / 0.5 h / -2 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 32 p. 10983 - 10992
反应条件
1: 95 percent / LiAlH4 / ethanol; various solvent(s) / 72 h / Heating 2: 85 percent / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 60, # 22 p. 4875 - 4878
