螺[吲哚啉-3,4’-哌啶]-1’-羧酸苄酯合成路线 （共 20 条）
反应条件
1: 17 g / aq. HCl / dioxane / 0.5 h / Heating 2: 95 percent / LiAlH4 / ethanol; various solvent(s) / 72 h / Heating 3: 85 percent / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 60, # 22 p. 4875 - 4878
反应条件
1: 99 percent / TFA / CH2Cl2 / 17 h / 35 °C 2: NaBH4 / toluene / 0.5 h / -2 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 32 p. 10983 - 10992
反应条件
1: potassium carbonate / 20 °C 2: pyridinium chlorochromate / dichloromethane / 20 °C 3: trifluoroacetic acid / dichloromethane 4: sodium tetrahydroborate / methanol View Scheme
参考文献
Chinese Chemical Letters, , vol. 23, # 6 p. 661 - 664
反应条件
1: pyridinium chlorochromate / dichloromethane / 20 °C 2: trifluoroacetic acid / dichloromethane 3: sodium tetrahydroborate / methanol View Scheme
参考文献
Chinese Chemical Letters, , vol. 23, # 6 p. 661 - 664
反应条件
1.1: water; sodium cyanoborohydride; acetic acid; methanol / 0 - 20 °C 1.2: pH 8 2.1: hydrogen / palladium 10 on activated carbon / methanol / 16 h View Scheme
参考文献
ELI LILLY AND COMPANY; HAMDOUCHI, Chafiq; LINESWALA, Jayana, Pankaj; MAITI, Pranab
Patent: WO2011/66183 A1, 2011 ;
WO 2011/066183 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C 1.2: 4 h 2.1: hydrogen / palladium 10 on activated carbon / methanol View Scheme
参考文献
MYREXIS, INC.; KUMAR, Dange Vijay; SLATTUM, Paul M.; YAGER, Kraig M.; SHENDEROVICH, Mark D.; TANGALLAPALLY, Rajendra; KIM, Se-Ho
Patent: WO2012/177782 A1, 2012 ;
WO 2012/177782 A1
反应条件
1: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C 2: 93 percent / H2 / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr 3: DCC, HOBt / H2O; various solvent(s) / 5 h / Ambient temperature 4: MsOH / ethanol / 7.5 h / 35 - 40 °C 5: DCC, HOBt / various solvent(s) / 2 h / Ambient temperature 6: MsOH / ethanol / 35 - 40 °C View Scheme
参考文献
Maligres, Peter E.; Houpis, Ioannis; Rossen, Kai; Molina, Audrey; Sager, Jess; Upadhyay, Veena; Wells, Kenneth M.; Reamer, Robert A.; Lynch, Joseph E.; Askin, David; Volante; Reider, Paul J.; Houghton, Peter
Tetrahedron, 1997 , vol. 53, # 32 p. 10983 - 10992
反应条件
acetic acid; palladium monocarbide in ethanol; dichloromethane
参考文献
Merck and Co., Inc.
Patent: US6013652 A1, 2000 ;
US 6013652 A
Title/Abstract Full Text Show Details
Merck and Co., Inc.
Patent: US5962462 A1, 1999 ;
US 5962462 A
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C;
参考文献
Eidam, Hilary Schenck; Haile, Pamela A.; Hughes, Terry Vincent; Sehon, Clark A.
Patent: US2008/318990 A1, 2008 ;
Location in patent: Page/Page column 22 ;
反应条件
1: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C 2: 93 percent / H2 / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr View Scheme
参考文献
Qi, Xian Liang; Yang, Er Qun; Zhang, Jun Tao; Wang, Tao; Cao, Xiao Ping
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 661 - 664
