1: 1-bromo-2-chloro-benzene; 2-methoxy-phenylmagnesium bromide With magnesium in tetrahydrofuran T=60°C; 2.5 h; 2: chloro-dicyclohexylphosphine With copper(l) chloride in tetrahydrofuran T=20°C; 16 h; Further stages.;
参考文献
Parrish; Buchwald
Journal of Organic Chemistry, 2001 , vol. 66, # 11 p. 3820 - 3827
Leeson, Paul D.; Emmett, John C.; Shah, Virendra P.; Showell, Graham A.; Novelli, Ricardo; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 320 - 336
1: 98 percent / diethyl ether; benzene / 1 h / Ambient temperature
2: 81 percent / acetic anhydride, aq. HI / 1 h / Heating
View Scheme
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
