6-氯-9-(beta-D-呋喃核糖基)-7-脱氮嘌呤合成路线 （共 9 条）
反应条件
DOWEX 50WX8-200 in methanol T=20°C; 8 h;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 13 p. 3934 - 3945
反应条件
trifluoroacetic acid in water 1 h; Ambient temperature;
参考文献
Ramasamy; Imamura; Robins; Revankar
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1893 - 1898
反应条件
1: 65 percent / KOH / tris<2-(2-methoxyethoxy)ethyl>amine / acetonitrile; tetrahydrofuran / 20 h 2: 89 percent / 90percent aq.CF3COOH / 1 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 71, # 6 p. 1573 - 1585
反应条件
1: CCl4, tris(dimethylamino)phosphane / tetrahydrofuran / 2 h / -78 °C 2: 65 percent / KOH / tris<2-(2-methoxyethoxy)ethyl>amine / acetonitrile; tetrahydrofuran / 20 h 3: 89 percent / 90percent aq.CF3COOH / 1 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 71, # 6 p. 1573 - 1585
反应条件
1: 1) sodium hydride (60percent in oil) / 1) acetonitrile, 0.5 h; 2) THF, RT, overnight 2: 99 percent / trifluoroacetic acid / H2O / 1 h / Ambient temperature View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 6 p. 1893 - 1898
反应条件
thiourea in ethanol 3 h; Reflux;
参考文献
Young, Ah Kim; Sharon, Ashoke; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Naguib, Fardos N. M.; El Kouni, Mahmoud H.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 13 p. 3934 - 3945
反应条件
ammonia in methanol T=50°C; 24 h;
参考文献
Rosemeyer; Seela
Helvetica Chimica Acta, 1988 , vol. 71, # 6 p. 1573 - 1585
反应条件
pyridine T=22°C; 4 h;
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
sodium hydride in tetrahydrofuran T=0 - 20°C;
参考文献
Young, Ah Kim; Sharon, Ashoke; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Naguib, Fardos N. M.; El Kouni, Mahmoud H.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 13 p. 3934 - 3945
