(2R,4R,5R)-2-(羟基甲基)-5-(5-甲硫基-2,4,9-三氮杂双环[4.3.0]壬-2,4,7,10-四烯-9-基)四氢呋喃-3,4-二醇合成路线 (共 6 条)
反应条件
1: 65 percent / KOH / tris<2-(2-methoxyethoxy)ethyl>amine / tetrahydrofuran 2: 68 percent / 10percent aq.CF3COOH View Scheme
参考文献
Rosemeyer; Seela
Helvetica Chimica Acta, 1988 , vol. 71, # 6 p. 1573 - 1585
反应条件
1: CCl4, tris(dimethylamino)phosphane / tetrahydrofuran / 2 h / -78 °C 2: 65 percent / KOH / tris<2-(2-methoxyethoxy)ethyl>amine / tetrahydrofuran 3: 68 percent / 10percent aq.CF3COOH View Scheme
参考文献
Rosemeyer; Seela
Helvetica Chimica Acta, 1988 , vol. 71, # 6 p. 1573 - 1585
反应条件
in ethanol T=20°C; 4 h;
参考文献
Naus, Petr; Caletkova, Olga; Konecny, Petr; Dzubak, Petr; Bogdanova, Katerina; Kolar, Milan; Vrbkova, Jana; Slavetinska, Lenka; Tloust'Ova, Eva; Perlikova, Pavla; Hajduch, Marian; Hocek, Michal
Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 1097 - 1110
反应条件
trifluoroacetic acid
参考文献
Rosemeyer; Seela
Helvetica Chimica Acta, 1988 , vol. 71, # 6 p. 1573 - 1585
反应条件
1: isopropylmagnesium chloride lithium chloride complex / tetrahydrofuran / 0.5 h / -10 °C 2: ethanol / 4 h / 20 °C View Scheme
参考文献
Naus, Petr; Caletkova, Olga; Konecny, Petr; Dzubak, Petr; Bogdanova, Katerina; Kolar, Milan; Vrbkova, Jana; Slavetinska, Lenka; Tloust'Ova, Eva; Perlikova, Pavla; Hajduch, Marian; Hocek, Michal
Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 1097 - 1110
反应条件
1: 81 percent / 80percent 3-chloroperbenzoic acid / methanol / 2 h / Ambient temperature 2: 75 percent / NH3 / methanol / 12 h / 50 °C View Scheme
参考文献
Rosemeyer; Seela
Helvetica Chimica Acta, 1988 , vol. 71, # 6 p. 1573 - 1585