甲基(2Z,4E,6Z,8Z)-3,7-二甲基-9-(2,6,6-三甲基-1-环己烯基)壬-2,4,6,8-四烯酸酯合成路线 （共 8 条）
反应条件
in methanol; hexane; benzene T=20°C; 0.75 h;
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 27 p. 6716 - 6729
反应条件
1: 1.) ethylmagnesium bromide / 1.) THF, r.t., 1.5 h; 2.) THF, r.t., 1 h 2: 81 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 55 °C 3: 60 percent / LiAlH4, titanium trichloride, triethylamine / tetrahydrofuran; diethyl ether / 0.5 h / 50 °C 4: 1.) collidine, silver nitrate; 2.) silica gel / 1.) acetonitrile; 2.) column chromatography with hexane-ether View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 130, p. 568 - 574
反应条件
1: 1.) ethylmagnesium bromide / 1.) THF, r.t., 1.5 h; 2.) THF, r.t., 1 h 2: 81 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 55 °C 3: 60 percent / LiAlH4, titanium trichloride, triethylamine / tetrahydrofuran; diethyl ether / 0.5 h / 50 °C 4: 1.) collidine, silver nitrate; 2.) silica gel / 1.) acetonitrile; 2.) column chromatography with hexane-ether View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 130, p. 568 - 574
反应条件
2,3,5-trimethyl-pyridine; silica gel; silver nitrate 1.) acetonitrile; 2.) column chromatography with hexane-ether; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bulletin de la Societe Chimique de France, , vol. 130, p. 568 - 574
参考文献
Journal of Physical Organic Chemistry, , vol. 9, # 6 p. 411 - 418
参考文献
Magnetic Resonance in Chemistry, , vol. 27, # 7 p. 707 - 709
反应条件
potassium hydroxide in methanol T=50°C; 2 h;
参考文献
Yamano, Yumiko; Ito, Masayoshi
Heterocycles, 1998 , vol. 47, # 1 p. 289 - 299
反应条件
1: LiAlH4; diethyl ether / -50 °C 2: petroleum ether; manganese (IV)-oxide / unter Lichtausschluss View Scheme
参考文献
Robeson et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 4111,4117
