2,4-二氯-5-(氯甲基)-6-甲基嘧啶合成路线 （共 3 条）
反应条件
tributyl-amine in trichlorophosphate T=90°C; 7 h; Heating / reflux;
参考文献
WO2005/110416 A2, ;
Page/Page column 60-61 ;
WO 2005/110416 A2
反应条件
1: 76.4 percent / KOH / 73 h / 50 °C 2: 60.1 percent / POCl3 / 1 h / Heating View Scheme
参考文献
Heterocycles, , vol. 63, # 11 p. 2523 - 2536
反应条件
1.1: 61.74 percent / sodium / 3 h / Heating
2.1: lithium diisopropylamide / hexane; tetrahydrofuran / 0.5 h / -70 - -55 °C
2.2: tetrahydrofuran; hexane / 3 h / -55 - -10 °C
2.3: 67.92 percent / ammonium chloride (satd.) / tetrahydrofuran; hexane / -10 - 20 °C
3.1: 5.5 h / Heating
3.2: 23.3 percent / water / 20 °C
View Scheme
参考文献
Batinac, Sanja; Sermek, Draginja Mrvos; Cetina, Mario; Pavelic, Kresimir; Mintas, Mladen; Raic-Malic, Silvana
Heterocycles, 2004 , vol. 63, # 11 p. 2523 - 2536
