[4-(2-甲基咪唑-1-基)苯基]甲醇合成路线 （共 6 条）
反应条件
sodium tetrahydroborate in methanol
参考文献
Pfizer Inc.
Patent: US5753682 A1, 1998 ;
反应条件
in methanol; hexane; dichloromethane
参考文献
Pfizer Inc.
Patent: US5883106 A1, 1999 ;
反应条件
in methanol; hexane; dichloromethane
参考文献
Pfizer Inc.
Patent: US5753682 A1, 1998 ;
反应条件
diisobutylaluminium hydride in hexane; dichloromethane T=-75 - 20°C;
参考文献
Mano, Takashi; Stevens, Rodney W.; Ando, Kazuo; Nakao, Kazunari; Okumura, Yoshiyuki; Sakakibara, Minoru; Okumura, Takako; Tamura, Tetsuya; Miyamoto, Kimitaka
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3879 - 3887
反应条件
1: 33 percent / potassium carbonate / dimethylsulfoxide / 66 h / 120 °C 2: 95 percent / diisobutylaluminum hydride / CH2Cl2; hexane / -75 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 18 p. 3879 - 3887
反应条件
1: 100 percent / SOCl2 / CH2Cl2 / 20 °C
2: 61 percent / K2CO3 / dimethylformamide / 120 °C
3: 96 percent / aq. LiOH / methanol; tetrahydrofuran / Heating
4: (COCl)2 / CH2Cl2 / 0 - 20 °C
5: NH3 / CH2Cl2 / 20 °C
View Scheme
参考文献
Mano, Takashi; Stevens, Rodney W.; Nakao, Kazunari; Okumura, Yoshiyuki; Kawamura, Kiyoshi; Ando, Akemi; Matsuoka, Yoko
Synthesis, 2004 , # 16 p. 2625 - 2628
