1-乙基-1,2,4-三唑合成路线 （共 12 条）
反应条件
T=170°C; 2 h; Microwave irradiation;
参考文献
CONCERT PHARMACEUTICALS, INC.; HARBESON, Scott, L.; TUNG, Roger, D.; LIU, Julie, F.
Patent: WO2011/5520 A1, 2011 ;
Location in patent: Page/Page column 32 ;
WO 2011/005520 A1
反应条件
1: 1-ethyl-1H-1,2,4-triazole With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexanes
T=-78°C; 2 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexanes
T=-78 - 20°C; 14 h;
参考文献
GLAXO GROUP LIMITED; BESWICK, Paul; MODI, Sandeep; PEGG, Neil; SKIDMORE, John; SWARBRICK, Martin
Patent: WO2004/24691 A1, 2004 ;
Location in patent: Page 37 ;
