3-溴-4-硝基吡啶-N-氧化物合成路线 （共 37 条）
反应条件
1: 2,4-dichloro-phenol With sodium hydroxide
2: 3-bromo-4-nitro-pyridine-1-oxide in acetonitrile
Heating;
参考文献
Julemont, Fabien; De Leval, Xavier; Michaux, Catherine; Renard, Jean-Francois; Winum, Jean-Yves; Montero, Jean-Louis; Damas, Jacques; Dogne, Jean-Michel; Pirotte, Bernard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6749 - 6759
参考文献
Julemont, Fabien; De Leval, Xavier; Michaux, Catherine; Renard, Jean-Francois; Winum, Jean-Yves; Montero, Jean-Louis; Damas, Jacques; Dogne, Jean-Michel; Pirotte, Bernard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6749 - 6759
反应条件
1.1: aq. NaOH
1.2: 45 percent / acetonitrile / 12 h / Heating
2.1: Fe; aq. acetic acid / 12 h / Heating
View Scheme
参考文献
Julemont, Fabien; De Leval, Xavier; Michaux, Catherine; Renard, Jean-Francois; Winum, Jean-Yves; Montero, Jean-Louis; Damas, Jacques; Dogne, Jean-Michel; Pirotte, Bernard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6749 - 6759
反应条件
1.1: aq. NaOH
1.2: 53 percent / acetonitrile / Heating
2.1: Fe; aq. acetic acid / Heating
View Scheme
参考文献
Julemont, Fabien; De Leval, Xavier; Michaux, Catherine; Renard, Jean-Francois; Winum, Jean-Yves; Montero, Jean-Louis; Damas, Jacques; Dogne, Jean-Michel; Pirotte, Bernard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6749 - 6759
反应条件
1: 55 percent / K2CO3 / toluene / 10 h / Heating
2: Fe; aq. acetic acid / Heating
3: K2CO3 / acetonitrile
View Scheme
参考文献
Julemont, Fabien; De Leval, Xavier; Michaux, Catherine; Renard, Jean-Francois; Winum, Jean-Yves; Montero, Jean-Louis; Damas, Jacques; Dogne, Jean-Michel; Pirotte, Bernard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6749 - 6759
反应条件
2: reducing agent <H>
View Scheme
参考文献
Yano, Yumihiko; Yatsu, Isao; Oya, Eiichi; Ohshima, Masashi
Chemistry Letters, 1983 , p. 775 - 778
反应条件
potassium hydroxide; tri[2-(2-methoxyethoxy)ethyl]amine; potassium carbonate in toluene
T=20°C; 1 h;
参考文献
YUHAN CORPORATION
Patent: WO2006/25715 A1, 2006 ;
Location in patent: Page/Page column 10 ;
WO 2006/025715 A1
反应条件
hydrogenchloride in methanol
T=22 - 26°C; 2 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; PAWAR, Mahesh Yashwant; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/38308 A1, 2013 ;
Location in patent: Page/Page column 36 ;
反应条件
1: 55 percent / K2CO3 / toluene / 10 h / Heating
2: Fe; aq. acetic acid / Heating
3: K2CO3 / acetonitrile
View Scheme
参考文献
Julemont, Fabien; De Leval, Xavier; Michaux, Catherine; Renard, Jean-Francois; Winum, Jean-Yves; Montero, Jean-Louis; Damas, Jacques; Dogne, Jean-Michel; Pirotte, Bernard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6749 - 6759
反应条件
1: 3,5-Dichlorophenol With sodium hydroxide
2: 3-bromo-4-nitro-pyridine-1-oxide in acetonitrile
Heating;
参考文献
Julemont, Fabien; De Leval, Xavier; Michaux, Catherine; Renard, Jean-Francois; Winum, Jean-Yves; Montero, Jean-Louis; Damas, Jacques; Dogne, Jean-Michel; Pirotte, Bernard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6749 - 6759
