反式-4-氨基环己烷羧酸乙酯合成路线 （共 8 条）
参考文献
Journal of medicinal chemistry, , vol. 14, # 17 p. 600 - 614
反应条件
hydrogenchloride in water 72 h; Reflux;
参考文献
Shonberg, Jeremy; Herenbrink, Carmen Klein; Lopez, Laura; Christopoulos, Arthur; Scammells, Peter J.; Capuano, Ben; Lane, J. Robert
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9199 - 9221
反应条件
hydrogen; 5 Ru/Al2O3 in diethylene glycol dimethyl ether T=120 - 170°C; P=15001.5 - 37503.8 Torr; 2 - 8 h; Product distribution / selectivity;
参考文献
JP2005/350392 A, ;
Page/Page column 9-10 ;
反应条件
in diethylene glycol dimethyl ether T=200°C; 5 h; Lactamization; Purification / work up;
参考文献
JP2005/350392 A, ;
Page/Page column 10 ;
反应条件
1: triethylamine / dichloromethane / 20 °C 2: diisobutylaluminium hydride / toluene / -78 °C / |Inert atmosphere View Scheme
参考文献
Shonberg, Jeremy; Herenbrink, Carmen Klein; Lopez, Laura; Christopoulos, Arthur; Scammells, Peter J.; Capuano, Ben; Lane, J. Robert
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9199 - 9221
反应条件
1: diethyl ether / 1.) 0 deg C, 1 h, 2.) ca.20 deg C, 2 h, 3.) 12 h 2: 35 percent / diethyl ether View Scheme
参考文献
Kosykhova, L. A.; Pikshilingaite, Yu.-V. K.; Mikul'skis, P. P.; Karpavichyus, K. I.; Knunyants, I. L.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1987 , vol. 36, # 9 p. 1896 - 1899
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1987 , # 9 p. 2045 - 2049
反应条件
1: diethyl ether / 1.) 0 deg C, 1 h, 2.) ca.20 deg C, 2 h, 3.) 12 h 2: 44 percent / Et3N / diethyl ether View Scheme
参考文献
Kosykhova, L. A.; Pikshilingaite, Yu.-V. K.; Mikul'skis, P. P.; Karpavichyus, K. I.; Knunyants, I. L.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1987 , vol. 36, # 9 p. 1896 - 1899
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1987 , # 9 p. 2045 - 2049
反应条件
1: 52 percent / H2O
2: 44 percent / SOCl2 / CHCl3 / 1 h / 20 °C
3: 89 percent / aq. HCl / 1.5 h / Heating
View Scheme
参考文献
Karpavichyus, K. I.; Prasmitskene, G. I.; Palaima, A. I.; Knunyants, I. L.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 1 p. 144 - 147
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 1 p. 165 - 169
