8-(氯甲基)咪唑并[1,2-a]吡啶盐酸盐合成路线 （共 3 条）
反应条件
thionyl chloride T=70 - 80°C; 8 h; Inert atmosphere;
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102142 A1, 2013 ;
Location in patent: Paragraph 0156 ;
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 6 h / 20 °C / |Inert atmosphere 1.2: 0.25 h / 0 - 20 °C 2.1: thionyl chloride / 8 h / 70 - 80 °C / |Inert atmosphere View Scheme
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102142 A1, 2013 ;
反应条件
1.1: sodium hydrogencarbonate / water; ethanol / 18 h / |Reflux; |Inert atmosphere 2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 6 h / 20 °C / |Inert atmosphere 2.2: 0.25 h / 0 - 20 °C 3.1: thionyl chloride / 8 h / 70 - 80 °C / |Inert atmosphere View Scheme
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102142 A1, 2013 ;
