3-[(4-硝基苯基)氨基]-1H-吲哚-2-甲醛合成路线 （共 8 条）
反应条件
trichlorophosphate T=20°C; Formylation; 20 h;
参考文献
Ryabova; Tugusheva; Alekseeva; Granik
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 7 p. 472 - 477
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=10°C; 1 h; 2: 3-[N-(4-nitrophenyl)amino]indole in water T=20 - 60°C;
参考文献
Tibotec Pharmaceuticals Ltd.
Patent: WO2004/46143 A1, 2004 ;
Location in patent: Page 38-40 ;
反应条件
potassium carbonate in acetone Cyclization; 0.25 h; Heating;
参考文献
Ryabova; Alekseeva; Granik
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 9 p. 579 - 584
反应条件
1: 64 percent / 0.42 h / boiling 2: 92 percent / triethylamine / methanol / 1 h / boiling 3: 98 percent / POCl3 / 20 h / 20 °C View Scheme
参考文献
Ryabova; Tugusheva; Alekseeva; Granik
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 7 p. 472 - 477
反应条件
1: 14.5 percent / sodium acetate / acetic acid / 8.5 h / 20 - 80 °C 2: 61 percent / potassium carbonate / acetone / 0.25 h / Heating View Scheme
参考文献
Ryabova; Alekseeva; Granik
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 9 p. 579 - 584
反应条件
1: 92 percent / triethylamine / methanol / 1 h / boiling 2: 98 percent / POCl3 / 20 h / 20 °C View Scheme
参考文献
Ryabova; Tugusheva; Alekseeva; Granik
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 7 p. 472 - 477
反应条件
potassium carbonate in acetone Methylation; 20 h; Heating;
参考文献
Ryabova; Alekseeva; Granik
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 9 p. 579 - 584
反应条件
sodium carbonate in toluene
3 h; Heating;
参考文献
Ryabova; Rastorgueva; Lisitsa; Alekseeva; Granik
Russian Chemical Bulletin, 2003 , vol. 52, # 6 p. 1386 - 1398
