2-疏基-5-甲氧基苯甲酸合成路线 （共 18 条）
反应条件
1: With hydrogenchloride; sodium nitrite
T=5°C;
2: With sulfur; sodium sulfide; sodium hydroxide
T=5°C;
3: With acetic acid; zinc
48 h; Heating;
参考文献
Sawwan, Nahed; Brzostowska, Edyta M.; Greer, Alexander
Journal of Organic Chemistry, 2005 , vol. 70, # 17 p. 6968 - 6971
反应条件
acetic acid; zinc
4 h; Heating;
参考文献
Archer; Zayed; Rej; Rugino
Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1240 - 1246
反应条件
potassium hydroxide in ethanol
Heating;
参考文献
Sauter,F.; Stuetz,P.
Monatshefte fuer Chemie, 1967 , vol. 98, p. 1962 - 1972
反应条件
1: SOCl2 / Heating
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 20 °C
3: 210 °C
4: aq. NaOH / Heating
View Scheme
参考文献
Sugiyama, Hideyuki; Yoshida, Masato; Mori, Kouji; Kawamoto, Tomohiro; Sogabe, Satoshi; Takagi, Terufumi; Oki, Hideyuki; Tanaka, Toshimasa; Kimura, Hiroyuki; Ikeura, Yoshinori
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 4 p. 613 - 624
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 20 °C
2: 210 °C
3: aq. NaOH / Heating
View Scheme
参考文献
Sugiyama, Hideyuki; Yoshida, Masato; Mori, Kouji; Kawamoto, Tomohiro; Sogabe, Satoshi; Takagi, Terufumi; Oki, Hideyuki; Tanaka, Toshimasa; Kimura, Hiroyuki; Ikeura, Yoshinori
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 4 p. 613 - 624
反应条件
hydrogenchloride; sodium hydroxide; sodium nitrite
Multistep reaction;
参考文献
Hollis Showalter; Angelo; Berman; Kanter; Ortwine; Ross-Kesten; Sercel; Turner; Werbel; Worth; Elslager; Leopold; Shillis
Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1527 - 1539
反应条件
1: 18.5 g / K2CO3, KI, Cu bronze / dimethylformamide / 18 h / Heating
2: 200 mg / conc. H2SO4 / 1.5 h / Heating
3: pyridine / 20 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
反应条件
1: 18.5 g / K2CO3, KI, Cu bronze / dimethylformamide / 18 h / Heating
2: 200 mg / conc. H2SO4 / 1.5 h / Heating
3: pyridine / 20 h / Heating
4: 1.7 g / 48percent HI / 3 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
反应条件
1: 18.5 g / K2CO3, KI, Cu bronze / dimethylformamide / 18 h / Heating
2: 200 mg / conc. H2SO4 / 1.5 h / Heating
3: 650 mg / 48percent HI, acetic acid / 2 h / Heating
4: 200 mg / pyridine / 16 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
反应条件
1: 18.5 g / K2CO3, KI, Cu bronze / dimethylformamide / 18 h / Heating
2: 200 mg / conc. H2SO4 / 1.5 h / Heating
3: pyridine / 20 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
