3-甲氧基-2-环己烯-1-酮合成路线 （共 49 条）
反应条件
1: 84 percent / LDA / tetrahydrofuran 2: DIBAL / hexane; CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Smith, Amos B.; Nolen, Ernest G.; Shirai, Ryuichi; Blase, Frances R.; Ohta, Mitsuaki; et al.
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7837 - 7848
反应条件
in tetrahydrofuran
2 h;
参考文献
Chandrasekhar; Reddy
Tetrahedron Asymmetry, 2002 , vol. 13, # 3 p. 261 - 268
参考文献
Mueller; Honaker
Journal of the American Chemical Society, 1951 , vol. 73, p. 2377
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Nasarow; Saw'jalow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1958 , p. 1233,1236;engl.Ausg.S.1190,1193
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1957 , p. 207,211;engl.Ausg.S.219,222
反应条件
n-butyllithium
1.) hexane, THF, -65 deg C, 30 min, 2.) THF, -65 deg C (15 min), room temperature (15 min); Yield given. Multistep reaction;
参考文献
Mphahlele, Malose J.; Modro, Tomasz A.
Journal of Organic Chemistry, 1995 , vol. 60, # 25 p. 8236 - 8240
反应条件
1: 91 percent
2: 75 percent / 660 °C / 30 - 40 Torr
3: acid
4: desilylation
View Scheme
参考文献
Paquette, Leo A.; Wells, Gregory J.; Horn, Keith A.; Yan, Tu-Hsin
Tetrahedron Letters, 1982 , vol. 23, # 3 p. 263 - 266
反应条件
hydrogenchloride; n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
参考文献
John Wyeth and Brother Limited
Patent: US4197241 A1, 1980 ;
反应条件
n-butyllithium; diisopropylamine
1.) hexane/THF, 0 to -10 deg C, 10 min, 2.) THF, amb. temp., 1.5 h; Yield given. Multistep reaction;
参考文献
Bradley; Cavalla; Edington; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
反应条件
lithium-sodium alloy
1.) hexane, mineral oil, reflux, 1.1 h; 2.) hexane, r.t., 30 min; Yield given. Multistep reaction;
参考文献
Oppolzer, Wolfgang; Zutterman, Freddy; Baettig, Kurt
Helvetica Chimica Acta, 1983 , vol. 66, # 2 p. 522 - 533
反应条件
1: With N-bromosuccinmide in benzene
T=0°C; 2.5 h;
2: With bis(cyclopentadienyl)titanium dichloride; zinc in tetrahydrofuran
T=20°C; Inert atmosphere;
3: With sulfuric acid in tetrahydrofuran; water
参考文献
Mandal; Paira; Roy
Journal of Chemical Sciences, 2010 , vol. 122, # 3 p. 423 - 426
反应条件
1: 73 percent
2: NaBH4, CeCl3 / tetrahydrofuran; H2O
3: 60 percent / toluene / Heating
4: 53 percent / O3
View Scheme
参考文献
Chandler; Parsons
Journal of the Chemical Society - Series Chemical Communications, 1984 , vol. NO. 5, p. 322 - 323
