1: With tBuCH2CH2B(H)NiPr2; triethylamine; triphenylphosphine; palladium dichloride in tetrahydrofuran T=65°C; Alcaraz-Vaultier borylation; 12 h; Inert atmosphere; 2: With methanol in tetrahydrofuran T=0°C; Inert atmosphere; Further stages;

1: With n-butyllithium in tetrahydrofuran; hexane T=-78 - 10°C; Inert atmosphere; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78°C; 1.5 h; Inert atmosphere;

1: 1-Bromo-3-fluoro-4-methylbenzene With n-butyllithium in tetrahydrofuran; hexane T=-50°C; Metallation; 0.5 h; 2: boric acid trimethyl ester in tetrahydrofuran; hexane T=20°C; Substitution; 12 h; 3: With hydrogenchloride in tetrahydrofuran; hexane Hydrolysis;

in diethyl ether