(S)-(-)-4-苄基-5,5-二甲基-2-恶唑烷酮合成路线 （共 31 条）
反应条件
lithium aluminium tetrahydride in diethyl ether T=-78°C; 0.5 h; Inert atmosphere;
参考文献
Herrmann, Aaron T.; Smith, Lindsay L.; Zakarian, Armen
Journal of the American Chemical Society, 2012 , vol. 134, # 16 p. 6976 - 6979
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78 - -50°C; 1 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 134, # 16 p. 6976 - 6979
反应条件
lithium hydroxide in tetrahydrofuran; water 1) 0 deg C, 1 h, 2) 0 deg C to room temperature;
参考文献
Davies, Stephen G.; Sanganee, Hitesh J.; Szolcsanyi, Peter
Tetrahedron, 1999 , vol. 55, # 11 p. 3337 - 3354
反应条件
1.1: tetrahydrofuran; diethyl ether / 0 - 20 °C 1.2: Cooling with ice 2.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 7 p. 797 - 811
反应条件
diphenyl phosphoryl azide; triethylamine in toluene T=80°C; 8 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 63, # 8 p. 2742 - 2748
反应条件
1: 99 percent / thionyl chloride / 2 h / Heating 2: diethyl ether / 6 h / Heating 3: 69.3 g / pyridine / 12 h / 0 - 20 °C 4: 90 percent / potassium carbonate / ethanol / 1 h / Heating View Scheme
参考文献
Organic Letters, , vol. 9, # 9 p. 1635 - 1638
反应条件
1: diethyl ether / 6 h / Heating 2: 69.3 g / pyridine / 12 h / 0 - 20 °C 3: 90 percent / potassium carbonate / ethanol / 1 h / Heating View Scheme
参考文献
Organic Letters, , vol. 9, # 9 p. 1635 - 1638
反应条件
tetrabutyl ammonium fluoride; acetic acid in tetrahydrofuran T=20°C; 16 h; Title compound not separated from byproducts;
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 2 p. 348 - 359
反应条件
1: With tetrabutyl ammonium fluoride; acetic acid in tetrahydrofuran T=20°C; 16 h; 2: With diisobutylaluminium hydride in dichloromethane T=-78°C; 0.333333 h; Title compound not separated from byproducts;
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 2 p. 348 - 359
反应条件
1.1: TiCl4; N,N-diisopropylethylamine / CH2Cl2 / 2 h / -78 °C 1.2: 97 percent / CH2Cl2 / 2 h / -78 - 20 °C 2.1: 92 percent / imidazole / dimethylformamide / 4 h / 60 °C 3.1: 84 percent / DIBAL-H / CH2Cl2; toluene / 0.33 h / -78 °C 4.1: 95 percent / sodium cyanoborohydride / ethanol / 4 h / Heating View Scheme
参考文献
Organic Letters, , vol. 9, # 9 p. 1635 - 1638
