(S)-(-)-4-苄基-5,5-二甲基-2-恶唑烷酮合成路线 （共 31 条）
反应条件
1: 92 percent / imidazole / dimethylformamide / 4 h / 60 °C 2: 84 percent / DIBAL-H / CH2Cl2; toluene / 0.33 h / -78 °C 3: 95 percent / sodium cyanoborohydride / ethanol / 4 h / Heating View Scheme
参考文献
Organic Letters, , vol. 9, # 9 p. 1635 - 1638
反应条件
1: 84 percent / DIBAL-H / CH2Cl2; toluene / 0.33 h / -78 °C 2: 95 percent / sodium cyanoborohydride / ethanol / 4 h / Heating View Scheme
参考文献
Organic Letters, , vol. 9, # 9 p. 1635 - 1638
反应条件
1: 69.3 g / pyridine / 12 h / 0 - 20 °C 2: 90 percent / potassium carbonate / ethanol / 1 h / Heating View Scheme
参考文献
Organic Letters, , vol. 9, # 9 p. 1635 - 1638
反应条件
1.1: LHMDS / tetrahydrofuran / -78 °C 1.2: 71 percent / tetrahydrofuran 2.1: DIBAL-H / CH2Cl2 / -78 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 17 p. 3475 - 3479
反应条件
1.1: LHMDS / tetrahydrofuran / -78 °C 1.2: 94 percent / tetrahydrofuran 2.1: DIBAL-H / CH2Cl2 / -78 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 17 p. 3475 - 3479
反应条件
1.1: LHMDS / tetrahydrofuran / -78 °C 1.2: 83 percent / tetrahydrofuran 2.1: DIBAL-H / CH2Cl2 / -78 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 17 p. 3475 - 3479
反应条件
1.1: tris(triphenylphosphine)ruthenium(II) chloride; zirconium tetrachloride; triethylamine / dichloromethane / 0.08 h / 22 - 24 °C / Inert atmosphere 1.2: 5 h / 24 - 45 °C / Inert atmosphere 2.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / -78 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 16 p. 6976 - 6979
反应条件
1.1: tris(triphenylphosphine)ruthenium(II) chloride; zirconium tetrachloride; triethylamine / dichloromethane / 0.08 h / -78 - 24 °C / Inert atmosphere 1.2: 17 h / -78 - 45 °C / Inert atmosphere 2.1: lithium hydroxide hydrate; dihydrogen peroxide / tetrahydrofuran; water / 6 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 16 p. 6976 - 6979
反应条件
1: N-ethyl-N,N-diisopropylamine / hexane; dichloromethane / -78 - 0 °C / Inert atmosphere 2: dichloromethane / -78 °C / Inert atmosphere 3: tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium / benzene / 12 h / 20 °C / Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 1 p. 543 - 555
反应条件
1: triethylamine / dichloromethane / 2 h / 22 - 24 °C / Inert atmosphere 2: tetrahydrofuran; diethyl ether / 36 h / 0 - 24 °C / Inert atmosphere 3: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 - 24 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 16 p. 6976 - 6979
