palladium on activated charcoal; hydrogen in ethanol T=20°C; 18 h;

C56H72IrNOP(1+)*C32H12BF24(1-); hydrogen; caesium carbonate in methanol T=60°C; P=4560.31 Torr; 12 h; Autoclave; enantioselective reaction;

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C 2: Chiralpak AD / methanol; ethanol; n-heptane / |Resolution of racemate 3: palladium on activated charcoal; hydrogen / ethanol / 18 h / 20 °C View Scheme

1: Chiralpak AD / methanol; ethanol; n-heptane / |Resolution of racemate 2: palladium on activated charcoal; hydrogen / ethanol / 18 h / 20 °C View Scheme

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C 2: trifluoroacetic acid / dichloromethane / 20 h / 20 °C 3: C56H72IrNOP(1+)*C32H12BF24(1-); caesium carbonate; hydrogen / methanol / 12 h / 60 °C / 4560.31 Torr / |Autoclave View Scheme

1: trifluoroacetic acid / dichloromethane / 20 h / 20 °C 2: C56H72IrNOP(1+)*C32H12BF24(1-); caesium carbonate; hydrogen / methanol / 12 h / 60 °C / 4560.31 Torr / |Autoclave View Scheme