hydrogen; magnesium oxide; palladium on activated charcoal in methanol T=45°C; P=2250.2 Torr; 65 h;

Candida antarctica lipase B; phosphate buffer in 1,4-dioxane T=40°C; pH=7; 36 h;

1: 2-Methoxyethyl methanesulphonate; 9-beta-D-arabinofuranosyladenine With sodium hydride; lithium bromide in dimethyl sulfoxide; N,N-dimethyl-formamide T=50 - 52°C; 3 h; 2: 2-Methoxyethyl methanesulphonate With potassium hydroxide in dimethyl sulfoxide 18 h; Further stages.;

phosphate buffer; Pseudomonas cepacia lipase in 1,4-dioxane T=60°C; pH=7; 168 h;

1: 1.) cc. H2SO4, 2.) NaH / 1.) 4 deg C, 16 h, 2.) DMF, 40 deg C 2: 125.9 g / SnCl4 / CH2Cl2 / 35 h / 3 °C 3: pyridine, 4-(dimethylamino)-pyridine / 17 h 4: 63 percent / BSA, TfOSiMe3 / 1,2-dichloro-ethane / 7 h / 70 °C 5: 96 percent / SOCl2 / dimethylformamide; CH2Cl2 / 5.5 h / 55 °C 6: 90 percent / tetrahydrofuran; methanol / 3 h / Ambient temperature 7: 78 percent / NaH / tetrahydrofuran / 9 h / 60 °C 8: 89 percent / NH3 / methanol / 6 h / 120 °C / 33752.7 Torr 9: 92 percent / H2, MgO / 5percent Pd/C / methanol / 65 h / 45 °C / 2250.2 Torr View Scheme

1: pyridine, 4-(dimethylamino)-pyridine / 17 h 2: 63 percent / BSA, TfOSiMe3 / 1,2-dichloro-ethane / 7 h / 70 °C 3: 96 percent / SOCl2 / dimethylformamide; CH2Cl2 / 5.5 h / 55 °C 4: 90 percent / tetrahydrofuran; methanol / 3 h / Ambient temperature 5: 78 percent / NaH / tetrahydrofuran / 9 h / 60 °C 6: 89 percent / NH3 / methanol / 6 h / 120 °C / 33752.7 Torr 7: 92 percent / H2, MgO / 5percent Pd/C / methanol / 65 h / 45 °C / 2250.2 Torr View Scheme

1: 63 percent / BSA, TfOSiMe3 / 1,2-dichloro-ethane / 7 h / 70 °C 2: 96 percent / SOCl2 / dimethylformamide; CH2Cl2 / 5.5 h / 55 °C 3: 90 percent / tetrahydrofuran; methanol / 3 h / Ambient temperature 4: 78 percent / NaH / tetrahydrofuran / 9 h / 60 °C 5: 89 percent / NH3 / methanol / 6 h / 120 °C / 33752.7 Torr 6: 92 percent / H2, MgO / 5percent Pd/C / methanol / 65 h / 45 °C / 2250.2 Torr View Scheme

1: 125.9 g / SnCl4 / CH2Cl2 / 35 h / 3 °C 2: pyridine, 4-(dimethylamino)-pyridine / 17 h 3: 63 percent / BSA, TfOSiMe3 / 1,2-dichloro-ethane / 7 h / 70 °C 4: 96 percent / SOCl2 / dimethylformamide; CH2Cl2 / 5.5 h / 55 °C 5: 90 percent / tetrahydrofuran; methanol / 3 h / Ambient temperature 6: 78 percent / NaH / tetrahydrofuran / 9 h / 60 °C 7: 89 percent / NH3 / methanol / 6 h / 120 °C / 33752.7 Torr 8: 92 percent / H2, MgO / 5percent Pd/C / methanol / 65 h / 45 °C / 2250.2 Torr View Scheme

1: 78 percent / NaH / tetrahydrofuran / 9 h / 60 °C 2: 89 percent / NH3 / methanol / 6 h / 120 °C / 33752.7 Torr 3: 92 percent / H2, MgO / 5percent Pd/C / methanol / 65 h / 45 °C / 2250.2 Torr View Scheme

1: 90 percent / tetrahydrofuran; methanol / 3 h / Ambient temperature 2: 78 percent / NaH / tetrahydrofuran / 9 h / 60 °C 3: 89 percent / NH3 / methanol / 6 h / 120 °C / 33752.7 Torr 4: 92 percent / H2, MgO / 5percent Pd/C / methanol / 65 h / 45 °C / 2250.2 Torr View Scheme