2’-O-(2-甲氧乙基)腺苷合成路线 （共 14 条）
反应条件
1: 96 percent / SOCl2 / dimethylformamide; CH2Cl2 / 5.5 h / 55 °C 2: 90 percent / tetrahydrofuran; methanol / 3 h / Ambient temperature 3: 78 percent / NaH / tetrahydrofuran / 9 h / 60 °C 4: 89 percent / NH3 / methanol / 6 h / 120 °C / 33752.7 Torr 5: 92 percent / H2, MgO / 5percent Pd/C / methanol / 65 h / 45 °C / 2250.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 78, # 2 p. 486 - 504
反应条件
1: 89 percent / NH3 / methanol / 6 h / 120 °C / 33752.7 Torr 2: 92 percent / H2, MgO / 5percent Pd/C / methanol / 65 h / 45 °C / 2250.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 78, # 2 p. 486 - 504
反应条件
potassium tert-butylate; lithium bromide in dimethyl sulfoxide T=50 - 52°C; 3 h;
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 26, # 10-12 p. 1237 - 1240
反应条件
sodium hydride in N,N-dimethyl-formamide 5 h;
参考文献
Werner, Doris; Brunar, Helmut; Noe, Christian R.
Pharmaceutica Acta Helvetiae, 1998 , vol. 73, # 1 p. 3 - 10
