(±)-吲哚啉-2-羧酸合成路线 （共 51 条）
反应条件
1: With sodium hydroxide in water T=170°C; P=5250.53 Torr; 3 h; Racemisation; 2: With hydrogenchloride in water T=20 - 25°C; pH=3.4;
参考文献
US2006/183919 A1, ;
Page/Page column 3 ;
反应条件
potassium hydroxide; stannous chloride in ethanol; water
反应条件
sulfuric acid; ammonia; lithium in tetrahydrofuran; dichloromethane; water; acetone
反应条件
potassium hydroxide in water; dimethyl sulfoxide Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 3 p. 394 - 403
反应条件
hydrogenchloride; sodium hydroxide in P2O5; water
反应条件
1: With acetic anhydride; acetic acid T=100°C; 3 h; 2: With hydrogenchloride; water T=100°C; 5 h; 3: With sodium hydroxide in water T=0 - 5°C; pH=2.0 - 2.5; 1 h; Product distribution / selectivity;
参考文献
WO2006/53440 A1, ;
Page/Page column 16-17 ;
反应条件
potassium hydroxide in methanol T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 1 p. 56 - 70
反应条件
1: 74 percent / Mg; MeOH / 20 °C 2: aq. KOH / methanol / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 1 p. 56 - 70
