(±)-吲哚啉-2-羧酸合成路线 （共 51 条）
反应条件
hydrogenchloride; hydrogen; palladium
参考文献
WO2004/99138 A2, ;
Page 7; 22; scheme ;
反应条件
1: 91 percent / thionyl chloride / 0 - 20 °C 2: 89 percent / triethylamine; 4-(dimethylamino)pyridine / tetrahydrofuran / 20 - 40 °C View Scheme
参考文献
Kuwano, Ryoichi; Sato, Koji; Kurokawa, Takashi; Karube, Daisuke; Ito, Yoshihiko
Journal of the American Chemical Society, 2000 , vol. 122, # 31 p. 7614 - 7615
反应条件
hydrogenchloride; sodium chloride; potassium carbonate in 1,4-dioxane; ethanol
参考文献
Sankyo Company, Limited
Patent: US5624935 A1, 1997 ;
反应条件
thionyl chloride 5 h; Heating;
参考文献
Lee, Sunkyung; Yi, Kyu Yang; Kim, Soo-Kyung; Suh, Jeehee; Kim, Nak Jeong; Yoo, Sung-Eun; Lee, Byung Ho; Seo, Ho Won; Kim, Sun-Ok; Lim, Hong
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 5 p. 459 - 471
反应条件
benzoic acid in 1,4-dioxane T=20°C; 24.1 h; Molecular sieveInert atmosphereReflux;
参考文献
Mao, Hui; Wang, Sichang; Yu, Peng; Lv, Huiqing; Xu, Runsheng; Pan, Yuanjiang
Journal of Organic Chemistry, 2011 , vol. 76, # 4 p. 1167 - 1169
反应条件
1: 75 percent / potassium carbonate / dimethylsulfoxide / 24 h / 95 - 100 °C 2: 80 percent / manganese(IV)oxide / CH2Cl2 View Scheme
参考文献
Chicharro, Roberto; De Castro, Sonia; Reino, Jose L.; Aran, Vicente J.
European Journal of Organic Chemistry, 2003 , # 12 p. 2314 - 2326
反应条件
hydrogenchloride in tetrahydrofuran; ethanol
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1223170 A1, 2002 ;
反应条件
1: 91 percent / thionyl chloride / 0 - 20 °C 2: 89 percent / triethylamine; 4-(dimethylamino)pyridine / tetrahydrofuran / 20 - 40 °C 3: 85 percent / DDQ / toluene / 24 h / Heating View Scheme
参考文献
Kuwano, Ryoichi; Sato, Koji; Kurokawa, Takashi; Karube, Daisuke; Ito, Yoshihiko
Journal of the American Chemical Society, 2000 , vol. 122, # 31 p. 7614 - 7615
反应条件
1: 52 percent / Et3N / CH2Cl2 / 2.75 h / 0 - 20 °C 3: 1.) 4-(dimethylamino)pyridine 5: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 6: 100 percent / 6 N HCl / 3 h / Heating View Scheme
参考文献
Kim, Dong H.; Guinosso, Charles J.; Buzby, George C.; Herbst, David R.; McCaully, Ronald J.; et al.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 394 - 403
反应条件
hydrogen; acetic acid; platinum(IV) oxide T=60°C; 24 h;
参考文献
Sayago, Francisco J.; Jimenez, Ana I.; Cativiela, Carlos
Tetrahedron Asymmetry, 2007 , vol. 18, # 19 p. 2358 - 2364
