(±)-吲哚啉-2-羧酸合成路线 （共 51 条）
反应条件
potassium hydroxide in N,N-dimethyl acetamide
T=60°C; Esterification; alkylation; 0.5 h;
参考文献
Popkov
Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 5 p. 544 - 547
反应条件
benzoic acid in 1,4-dioxane
T=20°C; 24.1 h; Molecular sieveInert atmosphereReflux;
参考文献
Mao, Hui; Wang, Sichang; Yu, Peng; Lv, Huiqing; Xu, Runsheng; Pan, Yuanjiang
Journal of Organic Chemistry, 2011 , vol. 76, # 4 p. 1167 - 1169
反应条件
N-ethyl-N,N-diisopropylamine; HATU in N,N-dimethyl-formamide
T=40°C;
参考文献
AERIE PHARMACEUTICALS, INC.
Patent: WO2007/8926 A1, 2007 ;
Location in patent: Page/Page column 37-38 ;
WO 2007/008926 A1
反应条件
thionyl chloride
T=0 - 20°C;
参考文献
Kuwano, Ryoichi; Sato, Koji; Kurokawa, Takashi; Karube, Daisuke; Ito, Yoshihiko
Journal of the American Chemical Society, 2000 , vol. 122, # 31 p. 7614 - 7615
反应条件
1: With sulfuric acid; nitric acid
T=-20 - -10°C; 0.5 h;
2: With sodium hydroxide in water
pH=4 - 5;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: WO2007/29847 A1, 2007 ;
Location in patent: Page/Page column 73 ;
反应条件
sulfuric acid; nitric acid
T=-20 - -10°C; 0.5 h;
参考文献
Lavrenov, Sergei N.; Lakatosh, Sergei A.; Lysenkova, Ludmila N.; Korolev, Alexander M.; Preobrazhenskaya, Maria N.
Synthesis, 2002 , # 3 p. 320 - 322
反应条件
1: 72 percent / H2SO4; HNO3 / 0.5 h / -20 - -10 °C
2: 90 percent / p-toluenesulfonic acid monohydrate / 0.5 h / Heating
View Scheme
参考文献
Lavrenov, Sergei N.; Lakatosh, Sergei A.; Lysenkova, Ludmila N.; Korolev, Alexander M.; Preobrazhenskaya, Maria N.
Synthesis, 2002 , # 3 p. 320 - 322
反应条件
sulfuric acid; nitric acid
T=-20 - -10°C; 0.5 h;
参考文献
Lavrenov, Sergei N.; Lakatosh, Sergei A.; Lysenkova, Ludmila N.; Korolev, Alexander M.; Preobrazhenskaya, Maria N.
Synthesis, 2002 , # 3 p. 320 - 322
反应条件
thionyl chloride
2 h; Heating;
参考文献
Alatorre-Santamaria, Sergio; Rodriguez-Mata, Maria; Gotor-Fernandez, Vicente; de Mattos, Marcos Carlos; Sayago, Francisco J.; Jimenez, Ana I.; Cativiela, Carlos; Gotor, Vicente
Tetrahedron Asymmetry, 2008 , vol. 19, # 14 p. 1714 - 1719
反应条件
thionyl chloride in methanol
参考文献
SmithKline Beecham Corporation
Patent: US5977101 A1, 1999 ;
