4-(2-苯基苯甲酰胺基)苯甲酸合成路线 （共 8 条）
反应条件
1: With sodium hydroxide in methanol; water 6 h; 2: With hydrogenchloride in water T=20°C;
参考文献
US2004/259857 A1, ;
Page 20 ;
反应条件
sodium hydroxide in ethanol
参考文献
US5719278 A1, ;
US 5719278 A
反应条件
sodium hydroxide in ethanol 18 h; Ambient temperature;
参考文献
Matsuhisa, Akira; Koshio, Hiroyuki; Sakamoto, Kenichiro; Taniguchi, Nobuaki; Yatsu, Takeyuki; Tanaka, Akihiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 10 p. 1566 - 1579
反应条件
1: 8.1 percent / WSC, HOBt / tetrahydrofuran / 240 h / Ambient temperature 2: 86 percent / 1 N NaOH / ethanol / 18 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 10 p. 1566 - 1579
反应条件
N,N-dimethyl-aniline in acetone T=25°C; 2 h;
参考文献
Tsunoda, Takashi; Yamazaki, Atsuki; Mase, Toshiyasu; Sakamoto, Shuichi
Organic Process Research and Development, 2005 , vol. 9, # 5 p. 593 - 598
反应条件
1: 8.1 percent / WSC, HOBt / tetrahydrofuran / 240 h / Ambient temperature 2: 86 percent / 1 N NaOH / ethanol / 18 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 46, # 10 p. 1566 - 1579
反应条件
1.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 3.5 h / 0 - 20 °C / |Inert atmosphere 1.2: 2.25 h / 0 - 20 °C 2.1: hydrogenchloride; acetic acid / 4 h / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 20 p. 8588 - 8602
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane 1 h;
参考文献
Deng, Xiaohu; Kenney, Birdella; Liang, Jimmy T.; Mani, Neelakandha; Villani, Frank J.; Zhang-Plasket, Fan; Zhong, Hua
Patent: US2004/259857 A1, 2004 ;
Location in patent: Page 26; 28 ;
