2-氨基-3-羟基吡啶合成路线 （共 143 条）
反应条件
1: 48 percent / K2CO3 / acetonitrile / 6 h / Heating 2: 70 percent / Sodium methoxide / methanol / 4 h / Heating 3: 82 percent / ethanol / 5 h / Heating 4: 39 percent / 8N aq. HCl / 0.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 21, # 4 p. 1081 - 1086
反应条件
(i) NaOMe, DMSO, (ii) /BRN= 506255/; Multistep reaction;
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 23, p. 2322 - 2324
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; [C8mim][BF4] T=20°C; 2 h; chemoselective reaction;
参考文献
Sharifi, Ali; Barazandeh, Mehdi; Saeed Abaee; Mirzaei, Mojtaba
Tetrahedron Letters, 2010 , vol. 51, # 14 p. 1852 - 1855
反应条件
in water stoich. amts. of CuBr and the pyridine are reacted in excessive dilute aq. HBr; soln. heated to remove excess of solvent;
参考文献
Willett, Roger D.
Acta Crystallographica, Section C: Crystal Structure Communications, 1988 , vol. 44, p. 450 - 453
反应条件
toluene-4-sulfonic acid
T=140°C; 8 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2004/838 A1, 2003 ;
Location in patent: Page 66-67 ;
WO 2004/000838 A1
反应条件
in ethanol
0.075 h; Microwave irradiation;
参考文献
Jain, Rajendra K.; Mishra, Anand P.
Journal of the Serbian Chemical Society, 2012 , vol. 77, # 8 p. 1013 - 1029,17
反应条件
sodium hydroxide; Adogen 464lt;*gt; in dichloromethane
T=25°C; 16 h;
参考文献
Bristol, James A.; Gross, Irwin; Lovey, Raymond G.
Synthesis, 1981 , # 12 p. 971 - 973
反应条件
pyridine
1.) 100 deg C, 1 h; 2.) 200 deg C, 0.5 h; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 9 p. 3168 - 3178
反应条件
sodium cyanoborohydride in tetrahydrofuran
参考文献
Hartz, Richard A.; Nanda, Kausik K.; Ingalls, Charles L.
Tetrahedron Letters, 2005 , vol. 46, # 10 p. 1683 - 1686
反应条件
PPA; trichlorophosphate
T=120°C; 3 h;
参考文献
Balogh, Maria; Hermecz, Istvan; Szilagyi, Ildiko; Meszaros, Zoltan
Heterocycles, 1983 , vol. 20, # 6 p. 1083 - 1088
