反应条件
1: 89 percent / pyridine / 0.08 h / Heating 2: 99 percent / potassium carbonate / H2O; acetone / Heating 3: N-bromosuccinimide / dimethylformamide / 1 h / 75 °C 4: 0.183 g / zinc / tris(dibenzylideneacetone)dipalladium(0); 1,1'-bis(diphenylphosphino)ferrocene / N,N-dimethyl-acetamide / 150 °C View Scheme
参考文献
Watterson, Scott H.; Chen, Ping; Zhao, Yufen; Gu, Henry H.; Dhar, T. G. Murali; Xiao, Zili; Ballentine, Shelley K.; Shen, Zhongqi; Fleener, Catherine A.; Rouleau, Katherine A.; Obermeier, Mary; Yang, Zheng; McIntyre, Kim W.; Shuster, David J.; Witmer, Mark; Dambach, Donna; Chao, Sam; Mathur, Arvind; Chen, Bang-Chi; Barrish, Joel C.; Robl, Jeffrey A.; Townsend, Robert; Iwanowicz, Edwin J.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3730 - 3742