2-氨基-3-羟基吡啶合成路线 （共 143 条）
反应条件
sodium hydroxide; tetra-(n-butyl)ammonium iodide in dichloromethane; water T=20°C; 120 h;
参考文献
Varga, Marton; Kapui, Zoltan; Batori, Sandor; Nagy, Lajos T.; Vasvari-Debreczy, Lelle; Mikus, Endre; Urban-Szabo, Katalin; Aranyi, Peter
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 4 p. 421 - 425
参考文献
Kawano, Tomikazu; Kato, Nobuo
Chemistry Letters, 2006 , vol. 35, # 3 p. 270 - 271
参考文献
Rydzkowski, R.; Blondeau, D.; Sliwa, H.
Tetrahedron Letters, 1985 , vol. 26, # 21 p. 2571 - 2574
反应条件
1.1: potassium hydroxide / ethanol; H2O 1.2: potassium permanganate; acetic acid 2.1: bromine / dimethylformamide View Scheme
参考文献
Ruefenacht,K. et al.
Helvetica Chimica Acta, 1976 , vol. 59, p. 1593 - 1612
反应条件
1: 66 percent / ethanol / 18 h / Heating 2: 75 percent / potassium carbonate / dimethylformamide / 1 h View Scheme
参考文献
Shao, Ning; Aslanian, Robert; West Jr., Robert E.; Williams, Shirley M.; Wu, Ren-Long; Hwa, Joyce; Sondey, Christopher; Lachowicz, Jean; Palani, Anandan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 2075 - 2078
反应条件
1: With pyridine; hydrogen fluoride; sodium nitrite T=0°C; 1 h; 2: With sodium hydroxide; water
参考文献
US2005/249662 A1, ;
Page/Page column 8-9 ;
反应条件
1: (i) NaOMe, DMSO, (ii) /BRN= 506255/ 2: LiAlH4 / diethyl ether View Scheme
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 23, p. 2322 - 2324
反应条件
1: 2-amino-3-hydroxy-pyridine With sodium hydroxide; water in methanol 2: chloroacetic acid in methanol
参考文献
WO2004/14384 A2, ;
Page/Page column 256; 262 ;
WO 2004/014384 A2
反应条件
sodium hydrogencarbonate in water; butanone 1.) room temperature, 30 min, 2.) 75 deg C, 30 min;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 6, # 2 p. 133 - 142
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; [C8mim][BF4] T=20°C; 1.5 h; chemoselective reaction;
参考文献
Tetrahedron Letters, , vol. 51, # 14 p. 1852 - 1855
