4-[[(1,1-二甲基乙氧基)羰基]氨基]-2-环戊烯-1-羧酸甲酯合成路线 （共 22 条）
反应条件
triethylamine in methanol; water
参考文献
Rey, Max; Welti, Gregor; Maryanoff, Cynthia
Patent: US2002/52524 A1, 2002 ;
反应条件
ammonium hydroxide; triethylamine in methanol; water
参考文献
Rey, Max; Welti, Gregor; Maryanoff, Cynthia
Patent: US2002/52524 A1, 2002 ;
反应条件
1: 1 N HCl / 10 h / Heating
2: 8.2 g / Et3N / CH2Cl2 / 1 h
View Scheme
参考文献
Chand; Montgomery; Kotian; Dehghani; El-Kattan; Lin; Hutchison; Babu; Bantia; Elliott
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4379 - 4392
反应条件
1: 62 percent / TMSN3, (+)-(1S,2S)-bis<2'-(diphenylphosphino)benzamido>-1,2-diphenylethane / Pd2(dba)3*CHCl3 / tetrahydrofuran / 1.5 h / -78 °C
2: PPh3 / tetrahydrofuran; H2O / 14 h / Ambient temperature
3: K2CO3 / tetrahydrofuran; H2O / 24 h / Ambient temperature
4: 96 percent / PPh3 / Pd2(dba)3*CHCl3 / tetrahydrofuran / 2 h / Ambient temperature
5: 47 percent / DBU, TBA oxone, Cs2CO3 / CH2Cl2 / 1.) r.t., 30 min, 2.) sonication, 4 h; r.t., 40 h
View Scheme
参考文献
Trost, Barry M.; Stenkamp, Dirk; Pulley, Shon R.
Chemistry--A European Journal, 1995 , vol. 1, # 8 p. 568 - 572
反应条件
TBA-Oxonereg;; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane
1.) r.t., 30 min, 2.) sonication, 4 h; r.t., 40 h;
参考文献
Trost, Barry M.; Stenkamp, Dirk; Pulley, Shon R.
Chemistry--A European Journal, 1995 , vol. 1, # 8 p. 568 - 572
反应条件
1: K2CO3 / tetrahydrofuran; H2O / 24 h / Ambient temperature
2: 96 percent / PPh3 / Pd2(dba)3*CHCl3 / tetrahydrofuran / 2 h / Ambient temperature
3: 47 percent / DBU, TBA oxone, Cs2CO3 / CH2Cl2 / 1.) r.t., 30 min, 2.) sonication, 4 h; r.t., 40 h
View Scheme
参考文献
Trost, Barry M.; Stenkamp, Dirk; Pulley, Shon R.
Chemistry--A European Journal, 1995 , vol. 1, # 8 p. 568 - 572
反应条件
1: PPh3 / tetrahydrofuran; H2O / 14 h / Ambient temperature
2: K2CO3 / tetrahydrofuran; H2O / 24 h / Ambient temperature
3: 96 percent / PPh3 / Pd2(dba)3*CHCl3 / tetrahydrofuran / 2 h / Ambient temperature
4: 47 percent / DBU, TBA oxone, Cs2CO3 / CH2Cl2 / 1.) r.t., 30 min, 2.) sonication, 4 h; r.t., 40 h
View Scheme
参考文献
Trost, Barry M.; Stenkamp, Dirk; Pulley, Shon R.
Chemistry--A European Journal, 1995 , vol. 1, # 8 p. 568 - 572
反应条件
triethylamine in dichloromethane
1 h;
参考文献
Chand; Montgomery; Kotian; Dehghani; El-Kattan; Lin; Hutchison; Babu; Bantia; Elliott
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4379 - 4392
反应条件
1: Et3N / methanol / 3 h / 20 °C
2: CH2Cl2 / 1 h
View Scheme
参考文献
Qiu, Jian; Pingsterhaus, Joyce M.; Silverman, Richard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 22 p. 4725 - 4728
反应条件
in dichloromethane
Esterification; 1 h;
参考文献
Qiu, Jian; Pingsterhaus, Joyce M.; Silverman, Richard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 22 p. 4725 - 4728
