2-甲氧基-5-氨基苯酚合成路线 （共 14 条）
反应条件
1: 1.) H2SO4, NaNO2, 2.) Cu2Br2, HBr / 1.) MeOH, H2O, 0 deg C, 45 min, 2.) H2O, reflux, 1.5 h
2: 100 percent / K2CO3 / acetone / 24 h / Heating
4: 1.) ammonium formate / 1.) 5percent Pd/C / 1.) MeOH, 1.5 h, 2.) toluene, reflux, 1.5 h
5: 1.) Li, NH3, 2.) Et3SiH-BF3*Et2O, TiCl4
View Scheme
参考文献
Meyers, A. I.; Snyder, Lawrence
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 36 - 42
反应条件
hydrogenchloride in water
T=100°C; 16 h;
参考文献
YALE UNIVERSITY
Patent: WO2007/38387 A2, 2007 ;
Location in patent: Page/Page column 45; 46 ;
反应条件
hydrogenchloride in water
T=100°C; 16 h;
参考文献
Hay, Michael P.; Turcotte, Sandra; Flanagan, Jack U.; Bonnet, Muriel; Chan, Denise A.; Sutphin, Patrick D.; Nguyen, Phuong; Giaccia, Amato J.; Denny, William A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 787 - 797
反应条件
1: Et3N / tetrahydrofuran / Ambient temperature
2: K2CO, NaI / butan-2-one / Heating
3: CF3CO2H / 0 °C
4: tetrahydrofuran / Ambient temperature
5: POCl3, N,N-dimethylaniline / 4 h / 110 °C
View Scheme
参考文献
Charpiot, Brigitte; Brun, Jvan; Donze, Irene; Naef, Reto; Stefani, Monique; Mueller, Thomas
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 20 p. 2891 - 2896
