hydrogenchloride; water T=105°C; 42 h;

Aspergillus niger lipase; sodium acetate buffer Title compound not separated from byproducts;

DCl T=130°C; 24 h; Title compound not separated from byproducts.;

1: thionyl chloride / 48 h / -10 - 20 °C / |Inert atmosphere 2: triethylamine / methanol / 17 h / 20 °C / |Inert atmosphere View Scheme

1: thionyl chloride / 48 h / -10 - 20 °C / |Inert atmosphere 2: triethylamine / methanol / 17 h / 20 °C / |Inert atmosphere 3: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 °C / |Reflux; |Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 20 h / 20 °C / |Inert atmosphere View Scheme

thionyl chloride T=-10 - 20°C; 48 h; Inert atmosphere;

hexamethylphosphorous triamide dichloride; ammonia in dichloromethane 1) 30 min, -20 deg C, 2) 4 h, r.t.;