1: 90 percent / NaH, TBAI / tetrahydrofuran / 1.) 15 min, 2.) 21 h 2: 97 percent / TBAF / tetrahydrofuran / 0.33 h 3: 97 percent / PPh3, imidazole, I2 / toluene / 1.) 60 deg C, 10 min, 2.) reflux, 3.75 h 4: 98 percent / DBU / xylene / 16.5 h / Heating 5: CAN / acetonitrile; H2O / 0.28 h / 0 °C View Scheme

1: 100 percent / 4-DMAP, pyridine / 36 h 2: 98 percent / NaBH4 / methanol / 2.5 h 3: 94 percent / DIEA / CH2Cl2 / 6 h 4: 100 percent / TBAF / tetrahydrofuran / 24 h 5: 69 percent / 4-DMAP / acetonitrile / 11.5 h 6: 0.25 h / 24 - 200 °C / 12 Torr 7: DIEA / methanol / 2 h 8: 93 percent / 2 N aq. HCl / methanol / 23 h / Heating 9: 100 percent / DIEA / methanol / 4 h View Scheme

1: 90 percent / NaH, TBAI / tetrahydrofuran / 1.) 15 min, 2.) 21 h 2: 97 percent / TBAF / tetrahydrofuran / 0.33 h 3: 97 percent / PPh3, imidazole, I2 / toluene / 1.) 60 deg C, 10 min, 2.) reflux, 3.75 h 4: 98 percent / DBU / xylene / 16.5 h / Heating 5: CAN / acetonitrile; H2O / 0.28 h / 0 °C 6: DMAP, pyridine / 22 h View Scheme