(3-氟-4-吗啉-4-基苯基)氨基甲酸苄酯合成路线 （共 14 条）
反应条件
1: [3-fluoro-4-(4-morpholinyl)phenyl]carbamic acid phenylmethyl ester With n-butyllithium 2: N-[(2S)oxiranylmethyl]acetamide
参考文献
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; MCCARTHY, James, R.
Patent: WO2011/137222 A1, 2011 ;
Location in patent: Example 2 ;
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 35 min, 2.) THF, hexane, -78 deg C, 1 h 2: 35.423 g / triethylamine / CH2Cl2 / 20 h 3: sodium azide / dimethylformamide / 16 h / 75 °C View Scheme
参考文献
J. Med. Chem., , vol. 39, # 3 p. 673 - 679
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -80 - -78 °C / |Inert atmosphere 1.2: 20 °C / |Cooling 2.1: triethylamine / dichloromethane / 45 °C 3.1: N,N-dimethyl-formamide / 3 h / 80 °C View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash Dhar; PRASAD, Ashok; JAIN, Kuldeep Natwarlal
Patent: WO2013/72923 A1, 2013 ;
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 35 min, 2.) THF, hexane, -78 deg C, 1 h 2: 35.423 g / triethylamine / CH2Cl2 / 20 h View Scheme
参考文献
JUBILANT LIFE SCIENCES LIMITED; GUPTA, Ashish, Kumar; SINGH, Shishupal; PANDA, Atulya, Kumar; BISWAS, Sujay; VIR, Dharam
Patent: WO2011/114210 A2, 2011 ;
