(S)-[N-3-(3'-氟-4'-吗啉基)苯基-2-氧代-5-噁唑烷合成路线 （共 18 条）
反应条件
copper(l) iodide; (1S,2S)-1,2-diaminocyclohexane; potassium carbonate in 1,4-dioxane T=110°C; Goldberg Reaction; 20 h; Inert atmosphere;
参考文献
Li, Yan-Wu; Liu, Yan; Jia, Yun-Can; Yuan, Jian-Yong
Chinese Chemical Letters, 2013 , vol. 24, # 3 p. 230 - 232
反应条件
in N,N-dimethyl-formamide T=80°C; 3 h;
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash Dhar; PRASAD, Ashok; JAIN, Kuldeep Natwarlal
Patent: WO2013/72923 A1, 2013 ;
Location in patent: Page/Page column 17 ;
反应条件
in N,N-dimethyl-formamide 5 h; Reflux;
参考文献
Reddy, Pingili Krishna; Mukkanti; Rao, Dodda Mohan
Oriental Journal of Chemistry, 2013 , vol. 29, # 3 p. 1015 - 1019
反应条件
in dichloromethane T=20°C; 20 h;
参考文献
WO2006/8754 A1, ;
Page/Page column 11 ;
反应条件
potassium carbonate in acetone T=20°C; 8 h;
参考文献
Tammana, Rajesh; Vemula, Kiran Kumar; Guruvindapalli, Ramadasu; Yanamandr, Ramesh; Gutta, Madhusudhan
Arkivoc, 2012 , vol. 2012, # 6 p. 45 - 56
反应条件
1: triethylamine / acetonitrile / 6 h / 40 - 50 °C / Reflux 2: hydrogen / Raney nickel / methanol / 8 h / 45 - 50 °C / 2942.29 Torr / Autoclave 3: tert-butyl alcohol / 16 h / Reflux 4: 1,1'-carbonyldiimidazole / dichloromethane / 24 h / 20 - 30 °C 5: N,N-dimethyl-formamide / 120 °C 6: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C 7: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice 8: N,N-dimethyl-formamide / 2 h / 120 °C View Scheme
反应条件
1: hydrogen / Raney nickel / methanol / 8 h / 45 - 50 °C / 2942.29 Torr / Autoclave 2: tert-butyl alcohol / 16 h / Reflux 3: 1,1'-carbonyldiimidazole / dichloromethane / 24 h / 20 - 30 °C 4: N,N-dimethyl-formamide / 120 °C 5: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C 6: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice 7: N,N-dimethyl-formamide / 2 h / 120 °C View Scheme
反应条件
1: methanol 2: N,N-dimethyl-formamide 3: dichloromethane View Scheme
参考文献
Asian Journal of Chemistry, , vol. 24, # 8 p. 3479 - 3482
反应条件
1: N,N-dimethyl-formamide 2: dichloromethane View Scheme
参考文献
Asian Journal of Chemistry, , vol. 24, # 8 p. 3479 - 3482
反应条件
1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice 2: N,N-dimethyl-formamide / 2 h / 120 °C View Scheme
