(S)-[N-3-(3'-氟-4'-吗啉基)苯基-2-氧代-5-噁唑烷合成路线 （共 18 条）
反应条件
1: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C 2: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice 3: N,N-dimethyl-formamide / 2 h / 120 °C View Scheme
反应条件
1: potassium carbonate / isopropyl alcohol / 5 h / Reflux 2: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere 3: potassium carbonate / dichloromethane / 20 °C 4: potassium carbonate / acetone / 8 h / 20 °C View Scheme
参考文献
Arkivoc, , vol. 2012, # 6 p. 45 - 56
反应条件
1: potassium carbonate / dichloromethane / 20 °C 2: potassium carbonate / acetone / 8 h / 20 °C View Scheme
参考文献
Arkivoc, , vol. 2012, # 6 p. 45 - 56
反应条件
1: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere 2: potassium carbonate / dichloromethane / 20 °C 3: potassium carbonate / acetone / 8 h / 20 °C View Scheme
参考文献
Arkivoc, , vol. 2012, # 6 p. 45 - 56
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -80 - -78 °C / |Inert atmosphere 1.2: 20 °C / |Cooling 2.1: triethylamine / dichloromethane / 45 °C 3.1: N,N-dimethyl-formamide / 3 h / 80 °C View Scheme
反应条件
1: N,N-dimethyl-formamide 2: dichloromethane View Scheme
参考文献
Asian Journal of Chemistry, , vol. 24, # 8 p. 3479 - 3482
反应条件
hydrazine hydrate in methanol 1 h; Reflux;
参考文献
Reddy, Pingili Krishna; Mukkanti; Rao, Dodda Mohan
Oriental Journal of Chemistry, 2013 , vol. 29, # 3 p. 1015 - 1019
反应条件
1: hydrazine hydrate / methanol / 1 h / Reflux 2: toluene / 1 h / 20 °C View Scheme
参考文献
Lee Pharma Limited; Alla, Raghu Mitra; Dubey, Ajay Kumar; Sirigiri, Aruna Kumari; Mareedu, Naga Kama Kumar
Patent: US2013/324719 A1, 2013 ;
