1: With N,N'-dimethyl-barbituric acid; palladium diacetate; triphenylphosphine in ethanol T=35°C; 5 h; Inert atmosphere; 2: With hydrogenchloride in dichloromethane; water pH=1; 3: With sodium hydroxide in water pH=10;
参考文献
Union Quimico Farmaceutica, S.A. (UQUIFA)
Patent: EP2163547 A1, 2010 ;
Location in patent: Page/Page column 11 ;