5-甲基-3-苯基-4-异唑甲酰氯合成路线 （共 19 条）
反应条件
(i) Et3N, CHCl3, dioxane, (ii) /BRN= 1082694/; Multistep reaction;
参考文献
Glombitza,K.-W.
Justus Liebigs Annalen der Chemie, 1964 , vol. 673, p. 166 - 170
反应条件
ammonium hydroxide in ethyl acetate pH=2 - 9;
参考文献
VARDHMAN CHEMTECH LIMITED; GUJRAL, Rajinder Singh; JAIN, Suyog
Patent: WO2012/164355 A1, 2012 ;
Location in patent: Page/Page column 12 ;
参考文献
Khisamutdinov,G.K. et al.
Pharmaceutical Chemistry Journal, 1967 , # 11 p. 633 - 634
Khimiko-Farmatsevticheskii Zhurnal, 1967 , # 11 p. 29 - 31
反应条件
hydrazine hydrate in diethyl ether; ethanol
参考文献
Khisamutdinov,G.K. et al.
Pharmaceutical Chemistry Journal, 1967 , # 11 p. 633 - 634
Khimiko-Farmatsevticheskii Zhurnal, 1967 , # 11 p. 29 - 31
反应条件
1.1: ethanol / 12 h / 0 - 20 °C
2.1: BuLi / tetrahydrofuran; hexane / 1 h / -70 °C
2.2: tetrahydrofuran; hexane / -70 - 20 °C
3.1: HCl / tetrahydrofuran / 20 °C
View Scheme
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
反应条件
1: CHCl3 / 0 - 20 °C
2: thionyl chloride / CHCl3 / 0 - 20 °C
3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, from -78 deg C to RT, overnigh
4: 64 percent / 3 N aq. HCl / Heating
5: 70 percent / LiAlH4
View Scheme
参考文献
Natale, N. R.; McKenna, John I.; Niou, Chorng-Shyr; Borth, Mark; Hope, Hakon
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5660 - 5666
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
反应条件
in ethanol
T=0 - 20°C; 12 h;
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
参考文献
Dietliker,K. et al.
Helvetica Chimica Acta, 1976 , vol. 59, p. 2074 - 2099
