4-(2-叔丁氧羰氨基乙氧基)-苯甲酸合成路线 （共 5 条）
反应条件
1: With lithium hydroxide hydrate in tetrahydrofuran; water T=20°C; 2: With hydrogenchloride in water pH=5;
参考文献
UNIVERSITY OF NOTTINGHAM; BAKER, Jillian G.; FISCHER, Peter M.; FROMONT, Christophe; GARDINER, Sheila M.; HILL, Stephen J.; JADHAV, Gopal; KELLAM, Barrie; MISTRY, Shailesh; WOOLARD, Jeanette
Patent: WO2012/104659 A1, 2012 ;
Location in patent: Page/Page column 37; 38 ;
WO 2012/104659 A1
反应条件
sodium hydroxide in ethanol T=20°C; saponification; 20 h;
参考文献
Duggan; Duong; Fisher; Hamill; Hoffman; Huff; Ihle; Leu; Nagy; Perkins; Rodan; Wesolowski; Whitman; Zartman; Hartman
Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3736 - 3745
反应条件
1: 100 percent / PPh3; DEAD / tetrahydrofuran; toluene / 20 h / 20 °C 2: 47 percent / 1 N NaOH / ethanol / 20 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 20 p. 3736 - 3745
反应条件
1: 100 percent / PPh3; DEAD / tetrahydrofuran; toluene / 20 h / 20 °C 2: 47 percent / 1 N NaOH / ethanol / 20 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 20 p. 3736 - 3745
反应条件
1.1: potassium carbonate / acetonitrile / Reflux 2.1: lithium hydroxide hydrate / water; tetrahydrofuran / 20 °C 2.2: pH 5 View Scheme
参考文献
WO2012/104659 A1, ;
WO 2012/104659 A1
